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    Host genetics role in the pathogenesis of periodontal disease and caries. 
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    Host genetics role in the pathogenesis of periodontal disease and caries.

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    Accepted version (106.4Kb)
    Volume
    44 Suppl 18
    Pagination
    S52 - S78
    DOI
    10.1111/jcpe.12639
    Journal
    J Clin Periodontol
    Metadata
    Show full item record
    Abstract
    BACKGROUND: This study aimed to produce the latest summary of the evidence for association of host genetic variants contributing to both periodontal diseases and caries. MATERIALS AND METHODS: Two systematic searches of the literature were conducted in Ovid Medline, Embase, LILACS and Cochrane Library for large candidate gene studies (CGS), systematic reviews and genome-wide association studies reporting data on host genetic variants and presence of periodontal disease and caries. RESULTS: A total of 124 studies were included in the review (59 for the periodontitis outcome and 65 for the caries outcome), from an initial search of 15,487 titles. Gene variants associated with periodontitis were categorized based on strength of evidence and then compared with gene variants associated with caries. Several gene variants showed moderate to strong evidence of association with periodontitis, although none of them had also been associated with the caries trait. CONCLUSIONS: Despite some potential aetiopathogenic similarities between periodontitis and caries, no genetic variants to date have clearly been associated with both diseases. Further studies or comparisons across studies with large sample size and clear phenotype definition could shed light into possible shared genetic risk factors for caries and periodontitis.
    Authors
    Nibali, L; Di Iorio, A; Tu, Y-K; Vieira, AR
    URI
    http://qmro.qmul.ac.uk/xmlui/handle/123456789/25146
    Collections
    • Centre for Oral Immunobiology and Regenerative Medicine [399]
    Language
    eng
    Licence information
    This is the peer reviewed version of the following article: Nibali L, Di Iorio A, Tu Y-K, Vieira AR. Host genetics role in the pathogenesis of periodontal disease and caries. J Clin Periodontol 2017; 44 (Suppl. 18): S52–S78. doi: 10.1111/jcpe.12639., which has been published in final form at http://dx.doi.org/10.1111/jcpe.12639. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
    Copyright statements
    © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
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