dc.contributor.author | Bédard, A | en_US |
dc.contributor.author | Northstone, K | en_US |
dc.contributor.author | Henderson, AJ | en_US |
dc.contributor.author | Shaheen, SO | en_US |
dc.date.accessioned | 2017-07-17T14:57:04Z | |
dc.date.available | 2017-05-05 | en_US |
dc.date.issued | 2017-07 | en_US |
dc.date.submitted | 2017-05-06T14:54:16.185Z | |
dc.identifier.uri | http://qmro.qmul.ac.uk/xmlui/handle/123456789/24893 | |
dc.description.abstract | The possible role of maternal consumption of free sugar during pregnancy in the inception of respiratory and atopic diseases has not been studied. We aimed to study the relationship between maternal intake of free sugar during pregnancy and respiratory and atopic outcomes in the offspring in a population-based birth cohort, the Avon Longitudinal Study of Parents and Children.We analysed associations between maternal intake of free sugar in pregnancy (estimated by a food frequency questionnaire), and current doctor-diagnosed asthma, wheezing, hay fever, eczema, atopy, serum total IgE and lung function in children aged 7-9 years (n=8956 with information on maternal diet in pregnancy and at least one outcome of interest).After controlling for potential confounders, maternal intake of free sugar was positively associated with atopy (OR for highest versus lowest quintile of sugar intake 1.38, 95% CI 1.06-1.78; per quintile p-trend=0.006) and atopic asthma (OR 2.01, 95% CI 1.23-3.29; per quintile p-trend=0.004). These associations were not confounded by intake of sugar in early childhood, which was unrelated to these outcomes.Our results suggest that a higher maternal intake of free sugar during pregnancy is associated with an increased risk of atopy and atopic asthma in the offspring, independently of sugar intake in early childhood. | en_US |
dc.description.sponsorship | The UK Medical Research Council, the Wellcome Trust (Grant 102215/2/13/2) and the University of
Bristol currently provide core support for the Avon Longitudinal Study of Parents and Children. A. Bédard is funded by
a European Respiratory Society Long-Term Research Fellowship (LTRF 2015-5838). K. Northstone is supported by the
National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care West at
University Hospitals Bristol NHS Foundation Trust. Funding information for this article has been deposited with the
Crossref Funder Registry | en_US |
dc.language | eng | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Eur Respir J | en_US |
dc.rights | Creative Commons Attribution Licence 4.0. | |
dc.subject | Adolescent | en_US |
dc.subject | Adult | en_US |
dc.subject | Asthma | en_US |
dc.subject | Child | en_US |
dc.subject | Dermatitis, Atopic | en_US |
dc.subject | Dietary Sucrose | en_US |
dc.subject | Female | en_US |
dc.subject | Humans | en_US |
dc.subject | Immunoglobulin E | en_US |
dc.subject | Linear Models | en_US |
dc.subject | Logistic Models | en_US |
dc.subject | Longitudinal Studies | en_US |
dc.subject | Male | en_US |
dc.subject | Mothers | en_US |
dc.subject | Pregnancy | en_US |
dc.subject | Prenatal Exposure Delayed Effects | en_US |
dc.subject | Prenatal Nutritional Physiological Phenomena | en_US |
dc.subject | Respiratory Sounds | en_US |
dc.subject | Rhinitis, Allergic, Seasonal | en_US |
dc.subject | United Kingdom | en_US |
dc.title | Maternal intake of sugar during pregnancy and childhood respiratory and atopic outcomes. | en_US |
dc.type | Article | |
dc.rights.holder | ©ERS 2017 | |
dc.identifier.doi | 10.1183/13993003.00073-2017 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/28679610 | en_US |
pubs.issue | 1 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published online | en_US |
pubs.volume | 50 | en_US |
dcterms.dateAccepted | 2017-05-05 | en_US |