• Login
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    in situ Nanomechanical Investigations of Bone 
    •   QMRO Home
    • Queen Mary University of London Theses
    • Theses
    • in situ Nanomechanical Investigations of Bone
    •   QMRO Home
    • Queen Mary University of London Theses
    • Theses
    • in situ Nanomechanical Investigations of Bone
    ‌
    ‌

    Browse

    All of QMROCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    ‌
    ‌

    Administrators only

    Login
    ‌
    ‌

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    in situ Nanomechanical Investigations of Bone

    View/Open
    HANGInSitu2011.pdf (5.450Mb)
    Metadata
    Show full item record
    Abstract
    Mineralized collagen fibrils(MCFs)are the fundamental building blocks that contribute to the extraordinary mechanical behaviour of bone. Despite its importance in defining bone mechanics, especially the high resistance to fracture recorded in bone tissue, MCFs have yet to be mechanically tested and and, thus, MCF contributions to the global mechanical properties of bone is unclear. In this thesis, a complete strategy for performing direct mechanical testing on nanosized fibrous samples including MCFs from bone using a novel in situ atomic force microscope (AFM) – scanning electron microscope (SEM) combination was scanning electron microscope (SEM) combination was established. This technique was used to mechanically test MCFs from antler bone tissue for the first time and resultant stress behaviour was recorded to highlight the inhomogeneous response of fibrils, which is associated with fibrillar compositional heterogeneity. Mechanical properties of MCFs and bone tissue were found to be controlled by biomineralization process using additional tensile testing of MCFs and bulk samples from mouse limb bones at different ages. Extrafibrillar mineralization was found to have effects on the Young’s modulus of bone tissue rather than fibrils, indicating the importance of fibrillar interfaces in controlling overall mechanical behaviour of bone tissue. Interfaces between fibrils in bone were examined by carrying out single fibril pullout tests. A weak but reformable interface, dominated by ionic bonds between fibrils, was recorded and the sacrificial bond reforming activity at the interface was found to be be dependent on pullout strain rate. Finally, considerations of bone as a fibrous composite was used to evaluate nanomechanical testing data, with approximately 50 % of the bone fracture energy accounted for in failure of fibril interfaces.
    Authors
    Hang, Fei
    URI
    http://qmro.qmul.ac.uk/xmlui/handle/123456789/2399
    Collections
    • Theses [3315]
    Twitter iconFollow QMUL on Twitter
    Twitter iconFollow QM Research
    Online on twitter
    Facebook iconLike us on Facebook
    • Site Map
    • Privacy and cookies
    • Disclaimer
    • Accessibility
    • Contacts
    • Intranet
    • Current students

    Modern Slavery Statement

    Queen Mary University of London
    Mile End Road
    London E1 4NS
    Tel: +44 (0)20 7882 5555

    © Queen Mary University of London.