Drug Design for CNS Diseases: Polypharmacological Profiling of Compounds Using Cheminformatic, 3D-QSAR and Virtual Screening Methodologies
Frontiers in Neuroscience
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The diverse cerebral mechanisms implicated in Central Nervous System (CNS) diseases together with the heterogeneous and overlapping nature of phenotypes indicated that multitarget strategies may be appropriate for the improved treatment of complex brain diseases. Understanding how the neurotransmitter systems interact is also important in optimizing therapeutic strategies....
AuthorsNikolic, K; Mavridis, L; Djikic, T; Vucicevic, J; Agbaba, D; Yelekci, K; Mitchell, JBO
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