An Investigation on the Aggregation and Rheodynamics of Human Red Blood Cells Using High Performance Computations
MetadataShow full item record
Studies on the haemodynamics of human circulation are clinically and scientifically important. The flow of human blood is extremely complex due to the existence of highly deformable red blood cells (RBCs) which are able to pass through capillaries smaller than their size. In order to investigate the effect of deformation and aggregation in blood flow, a computational technique has been developed by coupling the interaction between the fluid and the deformable RBCs. Parallelization was carried out for the coupled code and a high speedup was achieved based on a spatial decomposition and buffered data exchange. In order to verify the code’s capability of simulating RBC deformation and transport, simulations were carried out for a spherical capsule in a microchannel and multiple RBC transport in a Poiseuille flow. RBC transport in a confined tube was also carried out to simulate the peristaltic effects of microvessels. Relatively large-scale simulations were carried out of the motion of 49,512 RBCs in shear flows, which yielded a hematocrit of 45%. The large-scale feature of the simulation has enabled a macroscale verification and investigation of the overall characteristics of RBC aggregations to be carried out. The results are in excellent agreement with experimental studies and, more specifically, both the experimental and simulation results show uniform RBC distributions under high shear rates (60–100/s) whereas large aggregations were observed under a lower shear rate of 10/s.
AuthorsXu, D; Ji, C; AVITAL, E; Kaliviotis, E; Munjiza, A; Williams, JJR
- College Publications