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dc.contributor.authorNibali, L
dc.contributor.authorNovoa, L
dc.contributor.authorDonos, N
dc.contributor.authorHenderson, B
dc.contributor.authorBlanco, J
dc.contributor.authorTomas, I
dc.date.accessioned2017-03-09T12:34:05Z
dc.date.issued2016-03-10
dc.date.issued2016-12
dc.date.submitted2016-12-05T11:09:53.358Z
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/19777
dc.description.abstractBACKGROUND AND OBJECTIVE: Microbial recognition in the periodontium through specific leukocyte receptors gives rise to the response which in susceptible individuals can lead to periodontal diseases. The aim of this study was to explore the expression of leukocyte receptors in the gingival tissues of chronic periodontitis patients and to analyse differences between diseased and control sites (sites with probing pocket depth <4 mm). MATERIAL AND METHODS: Thirty-seven chronic periodontitis patients were included in the study. Gingival biopsies were harvested from diseased and control sites and processed by flow cytometry for the determination of the expression of 16 leukocyte receptors (CD4, CD8, CD11b, CD14, CD16, CD19, CD25, CD28, CD49d, CD49e, CD62, CD71, CD80, CCR7, Ly6G and HLA-DR). RESULTS: Expression of all studied receptors was higher in test compared with control sites (p < 0.005). Sampled sites with less bleeding on probing exhibited higher expression of CD16 and CD14 receptors (p = 0.020 and 0.011, respectively). CONCLUSIONS: This study points towards considerable differences in the expression of leukocyte receptors between diseased and control sites in the same periodontal patients.
dc.description.sponsorshipThis work was supported by project EM2014/025 from Regional Ministry of Culture, Education and University (regional government of Galicia, Spain), which is integrated in Regional Plan of Research, Innovation and Development 2011–2015.en_US
dc.format.extent2559 - 2564
dc.languageeng
dc.relation.ispartofClin Oral Investig
dc.rightsThe final publication is available at Springer via http://dx.doi.org/10.1007/s00784-016-1774-7
dc.subjectBacteria
dc.subjectLeukocyte receptors
dc.subjectPeriodontitis
dc.titleLeukocyte receptor expression in chronic periodontitis.
dc.typeJournal Article
dc.rights.holder© Springer-Verlag Berlin Heidelberg 2016
dc.identifier.doi10.1007/s00784-016-1774-7
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/26961374
pubs.issue9
pubs.organisational-group/Queen Mary University of London
pubs.organisational-group/Queen Mary University of London/Faculty of Medicine & Dentistry
pubs.organisational-group/Queen Mary University of London/Faculty of Medicine & Dentistry/Institute of Dentistry
pubs.organisational-group/Queen Mary University of London/Faculty of Medicine & Dentistry/Institute of Dentistry/Centre for Oral Clinical Research
pubs.publication-statusPublished
pubs.volume20


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