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    Osteoporotic Animal Models of Bone Healing: Advantages and Pitfalls. 
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    Osteoporotic Animal Models of Bone Healing: Advantages and Pitfalls.

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    Accepted version (53.30Mb)
    Volume
    30
    Pagination
    342 - 350
    DOI
    10.1080/08941939.2016.1241840
    Journal
    J Invest Surg
    Issue
    5
    Metadata
    Show full item record
    Abstract
    The aim of this review was to summarize the advantages and pitfalls of the available osteoporotic animal models of bone healing. A thorough literature search was performed in MEDLINE via OVID and EMBASE to identify animal studies investigating the effect of experimental osteoporosis on bone healing and bone regeneration. The osteotomy model in the proximal tibia is the most popular osseous defect model to study the bone healing process in osteoporotic-like conditions, although other well-characterized models, such as the post-extraction model, might be taken into consideration by future studies. The regenerative potential of osteoporotic bone and its response to biomaterials/regenerative techniques has not been clarified yet, and the critical size defect model might be an appropriate tool to serve this purpose. Since an ideal animal model for simulating osteoporosis does not exist, the type of bone remodeling, the animal lifespan, the age of peak bone mass, and the economic and ethical implications should be considered in our selection process. Furthermore, the influence of animal species, sex, age, and strain on the outcome measurement should be taken into account. In order to make future studies meaningful, standardized international guidelines for osteoporotic animal models of bone healing need to be set up.
    Authors
    Calciolari, E; Donos, N; Mardas, N
    URI
    http://qmro.qmul.ac.uk/xmlui/handle/123456789/19221
    Collections
    • Centre for Oral Immunobiology and Regenerative Medicine [399]
    Language
    eng
    Licence information
    This is an Accepted Manuscript of an article published by Taylor & Francis in Journal of Investigative Surgery on 08/12/2016, available online: http://www.tandfonline.com/10.1080/08941939.2016.1241840.
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