Finding Direction in the Search for Selection.
View/ Open
Volume
84
Pagination
39 - 50
DOI
10.1007/s00239-016-9765-5
Journal
J Mol Evol
Issue
Metadata
Show full item recordAbstract
Tests for positive selection have mostly been developed to look for diversifying selection where change away from the current amino acid is often favorable. However, in many cases we are interested in directional selection where there is a shift toward specific amino acids, resulting in increased fitness in the species. Recently, a few methods have been developed to detect and characterize directional selection on a molecular level. Using the results of evolutionary simulations as well as HIV drug resistance data as models of directional selection, we compare two such methods with each other, as well as against a standard method for detecting diversifying selection. We find that the method to detect diversifying selection also detects directional selection under certain conditions. One method developed for detecting directional selection is powerful and accurate for a wide range of conditions, while the other can generate an excessive number of false positives.
Authors
Thiltgen, G; Dos Reis, M; Goldstein, RACollections
Language
Licence information
Copyright statements
Related items
Showing items related by title, author, creator and subject.
-
Estimating the distribution of selection coefficients from phylogenetic data using sitewise mutation-selection models.
Tamuri, AU; dos Reis, M; Goldstein, RA (2012-03)Estimation of the distribution of selection coefficients of mutations is a long-standing issue in molecular evolution. In addition to population-based methods, the distribution can be estimated from DNA sequence data by ... -
The role of sexual selection in adaptation to novel environments and the effects of environmental change on sexual selection
Parrett, Jonathan Michael (Queen Mary University of London, 2018-05-01)Sexual selection is ubiquitous in all sexually reproducing species and a powerful evolutionary force. The effect of sexual selection on population fitness has caused wide debate and has been proposed to both enhance ... -
Cluster Heads Selection and Cooperative Nodes Selection for Cluster-based Internet of Things Networks
Song, Liumeng (Queen Mary University of London, 2017-01-12)Clustering and cooperative transmission are the key enablers in power-constrained Internet of Things (IoT) networks. The challenges for power-constrained devices in IoT networks are to reduce the energy consumption and ...