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dc.contributor.authorThiltgen, G
dc.contributor.authorDos Reis, M
dc.contributor.authorGoldstein, RA
dc.date.accessioned2016-12-12T14:56:56Z
dc.date.issued2016-12
dc.date.issued2016-12-02
dc.date.submitted2016-12-06T21:54:59.994Z
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/18197
dc.description.abstractTests for positive selection have mostly been developed to look for diversifying selection where change away from the current amino acid is often favorable. However, in many cases we are interested in directional selection where there is a shift toward specific amino acids, resulting in increased fitness in the species. Recently, a few methods have been developed to detect and characterize directional selection on a molecular level. Using the results of evolutionary simulations as well as HIV drug resistance data as models of directional selection, we compare two such methods with each other, as well as against a standard method for detecting diversifying selection. We find that the method to detect diversifying selection also detects directional selection under certain conditions. One method developed for detecting directional selection is powerful and accurate for a wide range of conditions, while the other can generate an excessive number of false positives.
dc.description.sponsorshipThis work was supported by the Medical Research Council (UK) (MC U117573).en_US
dc.languageeng
dc.relation.ispartofJ Mol Evol
dc.relation.isreplacedby123456789/18416
dc.relation.isreplacedbyhttp://qmro.qmul.ac.uk/xmlui/handle/123456789/18416
dc.relation.isreplacedbyhttps://qmro.qmul.ac.uk/handle/123456789/18416
dc.rightsThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
dc.subjectDirectional selection
dc.subjectDiversifying selection
dc.subjectPositive selection
dc.subjectd N/d S
dc.titleFinding Direction in the Search for Selection.
dc.typeJournal Article
dc.rights.holder© The Author(s) 2016
dc.identifier.doi10.1007/s00239-016-9765-5
pubs.author-urlhttp://www.ncbi.nlm.nih.gov/pubmed/27913840
pubs.declined2016-12-06T21:55:27.757+0000
pubs.deleted2016-12-06T21:55:27.757+0000
pubs.merge-to123456789/18416
pubs.merge-tohttp://qmro.qmul.ac.uk/xmlui/handle/123456789/18416
pubs.merge-tohttps://qmro.qmul.ac.uk/handle/123456789/18416
pubs.publication-statusPublished online


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