Mesenchymal Stem Cell Magnetization: Magnetic Multilayer Microcapsule Uptake, Toxicity, Impact on Functional Properties, and Perspectives for Magnetic Delivery.
View/ Open
Volume
5
Pagination
3182 - 3190
DOI
10.1002/adhm.201600843
Journal
Adv Healthc Mater
Issue
Metadata
Show full item recordAbstract
Mesenchymal stem cells (MSCs) are widely used in cell therapy due to their convenience, multiline differentiation potential, reproducible protocols, and biological properties. The potential of MSCs to impregnate magnetic microcapsules and their possible influence on cell function and ability to response to magnetic field have been explored. Interestingly, the cells suspended in media show much higher ability in internalization of microcapsules, then MSCs adhere into the surface. There is no significant effect of microcapsules on cell toxicity compared with other cell line-capsule internalization reported in literature. Due to internalization of magnetic capsules by the cells, such cell engineering platform is responsive to external magnetic field, which allows to manipulate MSC migration. Magnetically sorted MSCs are capable to differentiation as confirmed by their conversion to adipogenic and osteogenic cells using standard protocols. There is a minor effect of capsule internalization on cell adhesion, though MSCs are still able to form spheroid made by dozen of thousand MSCs. This work demonstrates the potential of use of microcapsule impregnated MSCs to carry internalized micron-sized vesicles and being navigated with external magnetic signaling.
Authors
Lepik, KV; Muslimov, AR; Timin, AS; Sergeev, VS; Romanyuk, DS; Moiseev, IS; Popova, EV; Radchenko, IL; Vilesov, AD; Galibin, OVCollections
Language
Licence information
Copyright statements
Related items
Showing items related by title, author, creator and subject.
-
WS02a: Making the Human Body Transparent: The Impact of Nuclear Magnetic Resonance and Magnetic Resonance Imaging (02-Jul-1996)
History of Twentieth Century Medicine Group; History of Modern Biomedicine Research Group (18/05/2017)Selection of photos taken at the Witness Seminar “Making the Body More Transparent: The Impact of Nuclear Magnetic Resonance and Magnetic Resonance Imaging” held by the History of Twentieth Century Medicine Group, 02-Jul-1996. ... -
Possible health effects of magnetic fields
MARINAKIS, S; Howard,, B (2015-12-16)There is a major public concern about possible detrimental health effects of weak magnetic fields. Our research will provide the first systematic and detailed study of magnetic properties of important radical-containing ... -
Role of electron inertia and reconnection dynamics in a stressed X-point collapse with a guide-field
von der Pahlen, JG; Tsiklauri, D (2016-11)