This is the peer reviewed version of the following article: Fibroblast activation and senescence in oral cancer. Prime SS, Cirillo N, Hassona Y, Lambert DW, Paterson IC, Mellone M, Thomas GJ, James EN, Parkinson EK. J Oral Pathol Med. 2016 May 30. doi: 10.1111/jop.12456, which has been published in final form at https://dx.doi.org/10.1111/jop.12456. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.