Cardiac Remodeling: Novel Insights From MESA.
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Cardiac remodeling frequently leads to heart failure with substantial mortality, morbidity, and economic burden to society. The prevalence of heart failure is approximately 2% to 4% of the population in Europe with a major impact on health care expenditure (1). Both the incidence and prevalence of heart failure will increase due to an aging population, an increasing prevalence of diabetes and hypertension, and the improved prognosis of most cardiovascular diseases. Despite the astronomical burden of the disease due to maladaptive cardiac remodeling, our current understanding of the interplay of nongenetic and genetic factors contributing to the remodeling process is still limited.
- Cardiovascular