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    Fibroblast activation and senescence in oral cancer. 
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    Fibroblast activation and senescence in oral cancer.

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    Accepted version (845.3Kb)
    Publisher
    Wiley Online
    DOI
    10.1111/jop.12456
    ISSN
    0904-2512
    Metadata
    Show full item record
    Abstract
    There is now compelling evidence that the tumour stroma plays an important role in the pathogenesis of cancers of epithelial origin. The pre-eminent cell type of the stroma is carcinoma-associated fibroblasts. These cells demonstrate remarkable heterogeneity with activation and senescence being common stress responses. In this review, we summarise the part that these cells play in cancer, particularly oral cancer, and present evidence to show that activation and senescence reflect a unified programme of fibroblast differentiation. We report advances concerning the senescent fibroblast metabolome, mechanisms of gene regulation in these cells and ways in which epithelial cell adhesion is dysregulated by the fibroblast secretome. We suggest that the identification of fibroblast stress responses may be a valuable diagnostic tool in the determination of tumour behaviour and patient outcome. Further, the fact that stromal fibroblasts are a genetically stable diploid cell population suggests that they may be ideal therapeutic targets and early work in this context is encouraging.
    Authors
    Prime, SS; Cirillo, N; Hassona, Y; Lambert, DW; Paterson, IC; Mellone, M; Thomas, GJ; James, EN; Parkinson, EK
    URI
    http://qmro.qmul.ac.uk/xmlui/handle/123456789/15589
    Collections
    • Centre for Oral Immunobiology and Regenerative Medicine [466]
    Language
    ENG
    Licence information
    "This is the peer reviewed version of the following article: Prime SS, Cirillo N, Hassona Y, Lambert DW, Paterson IC, Mellone M, Thomas GJ, James EN, Parkinson EK. Fibroblast activation and senescence in oral cancer. J Oral Pathol Med (2017) 46: 82–88, which has been published in final form at http://dx.doi.org10.1111/jop.12456. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."
    Copyright statements
    John Wiley and Sons 2016. John Wiley & Sons
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