• Login
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    Psychological stress and hypnosis in ulcerative colitis. 
    •   QMRO Home
    • Queen Mary University of London Theses
    • Theses
    • Psychological stress and hypnosis in ulcerative colitis.
    •   QMRO Home
    • Queen Mary University of London Theses
    • Theses
    • Psychological stress and hypnosis in ulcerative colitis.
    ‌
    ‌

    Browse

    All of QMROCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    ‌
    ‌

    Administrators only

    Login
    ‌
    ‌

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Psychological stress and hypnosis in ulcerative colitis.

    View/Open
    MAWDSLEYPsychologicalStress2008.pdf (38.17Mb)
    Metadata
    Show full item record
    Abstract
    Previous studies suggest that life events and chronic stress increase the risk of relapse in inflammatory bowel disease. Furthermore, experimental stress has been shown to worsen inflammation in animal models of colitis. Hypnotherapy is effective for functional gastrointestinal (GI) disorders and claimed by some patients to improve ulcerative colitis (UC). Two major hypotheses are tested in this thesis: i) Psychological stress can worsen inflammation via its effects on various systemic and rectal mucosal inflammatory variables in quiescent UC. ii) Relaxation achieved through hypnosis can reduce inflammation via its effects on various systemic and mucosal inflammatory variables in active UC. Patients with UC and healthy controls underwent an experimental stress test, hypnotherapy session or control procedure. Various systemic and, in patients with UC, rectal mucosal inflammatory measures were assessed before and after each procedure. The major findings are as follows: i) In patients with inactive UC, acute experimental stress increased LPS stimulated TNF-a and IL-6 production by whole blood. Stress also increased leukocyte count, Natural Killer (NK) cell count, platelet activation and platelet-leukocyte aggregate (PLA) formation. At the mucosal level, stress increased TNF-a in perimucosal fluid, and mucosal ROM production; it reduced rectal mucosal blood flow (RMBF). ii) In patients with active UC, one session of hypnotherapy reduced serum IL-6 concentration and caused a transient reduction in NK cell numbers. At the mucosal level, hypnotherapy caused a reduction in the concentration in peri-mucosal fluid of Substance P, histamine and IL-13 and reduced RMBF. iii) Chronic stress, as assessed by psychometric questionnaires,d id not affect the response to acute experimental stress. iv) There was no difference between the responses of patients with UC and healthy volunteers to any protocol. In conclusion, stress increased, whilst hypnotherapy reduced various inflammatory measures at both the systemic and mucosal level in patients with UC. These effects might contribute to the reported adverse effects of stress and therapeutic efficacy of hypnotherapy in UC.
    Authors
    Mawdsley, Joel Evan David
    URI
    http://qmro.qmul.ac.uk/xmlui/handle/123456789/1540
    Collections
    • Theses [3822]
    Copyright statements
    The copyright of this thesis rests with the author and no quotation from it or information derived from it may be published without the prior written consent of the author
    Twitter iconFollow QMUL on Twitter
    Twitter iconFollow QM Research
    Online on twitter
    Facebook iconLike us on Facebook
    • Site Map
    • Privacy and cookies
    • Disclaimer
    • Accessibility
    • Contacts
    • Intranet
    • Current students

    Modern Slavery Statement

    Queen Mary University of London
    Mile End Road
    London E1 4NS
    Tel: +44 (0)20 7882 5555

    © Queen Mary University of London.