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dc.contributor.authorMa, Jia
dc.identifier.citationMa, J. 2011. Processing of Polymer-based Systems for Improved Performance and Controlled Release. Queen Mary University of Londonen_US
dc.description.abstractThis thesis focuses on i proved processing methods for enhanced mechanical properties in polymer nanocomposites, and controlled drug release in polymer based delivery systems. Supercritical carbon dioxide assisted mixing was successfully used in preparation of polypropylene/sepiol ite and polypropylene/multiwall carbon nanotube nanocomposites. Relatively homogeneous dispersed and well separated nanofillers were obtained throughout the PP matrix. A better preservation of nanofiller lengths was observed in the scCO 2 assisted mixing. Mechanical property studies showed a marked increase in Young’s modulus and tensile strength with the addition of nanofillers. More interestingly, techniques usually designed to achieve high quality PP nanocomposites, such as the use of masterbatches, maleic anhydride grafted polypropylene compatibilizers or polymer coated MWNTs are not needed to achieve equivalent mechanical properties with scCO2 assisted mixing. ScCO2 was also used as a foaming technique to modify the traditional cured poly(ethyl methacrylate/tetrahydrofurfuryl methacrylate) system for a controlled release of chlorhexidine. Highly porous structures were produced and chlorhexidine released from scCO2 foamed samples was more than 3 times higher than traditionally cured samples. By altering the proc essing conditions, such as CO 2 saturation time and depressurization time the CX releas e rate was altered. Finally , the electrospinning method was combined with the layering encap sulation technique in order to enable the incorporation of water-soluble drugs in poly(lactic-co-glycolic acid) fibres for biomedical applications. Water-soluble drug, Rhodamine 6G or protein bovine serum albumin, loaded calcium carbonate microparticles were successfully incorporated i n PLGA fibres and a bead and string structured composite fibres.en_US
dc.publisherQueen Mary University of Londonen_US
dc.subjectpolymer nanocompositesen_US
dc.subjectPolymer based delivery systemsen_US
dc.subjectcontrolled drug releaseen_US
dc.titleProcessing of Polymer-based Systems for Improved Performance and Controlled Releaseen_US
dc.rights.holderThe copyright of this thesis rests with the author and no quotation from it or information derived from it may be published without the prior written consent of the author

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  • Theses [3930]
    Theses Awarded by Queen Mary University of London

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