• Login
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    Studies of cartilage degradation in vivo 
    •   QMRO Home
    • Queen Mary University of London Theses
    • Theses
    • Studies of cartilage degradation in vivo
    •   QMRO Home
    • Queen Mary University of London Theses
    • Theses
    • Studies of cartilage degradation in vivo
    ‌
    ‌

    Browse

    All of QMROCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    ‌
    ‌

    Administrators only

    Login
    ‌
    ‌

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Studies of cartilage degradation in vivo

    View/Open
    AL-DUAIJStudiosOn1985.pdf (13.01Mb)
    Publisher
    Queen Mary University of London
    Metadata
    Show full item record
    Abstract
    A new method has been established to study cartilage breakdown in vivo. Cartilage was implanted into air pouches on the backs of mice or rats and loss of proteoglycan measured biochemically. Using the air pouch it was possible to produce various inflammatory environments either immune or non immune and examine the effects of these upon proteoglycan loss. It was found that the various type of inflammation failed to accelerate proteoglycan loss from implanted cartilage. Subsequently a variety of drugs used in the treatment of the arthropathies were examined for their effect on both inflammation and cartilage breakdown. Using xiphisternum a difference could be shown between non-steroidal anti-inflammatory drugs (NSAID) and d-penicillamine in that, NSAID failed to protect the cartilage whereas d-penicillamine prevented proteoglycan loss. This type of cartilage was not examined further, as it was not characteristic of articular cartilage - being surrounded by perichondrium. Later articular cartilage was implanted once again into different inflammatory situations and drug effects evaluated. It was found using this cartilage that all the drug 0 used protected from loss of proteoglycan and whereas some inhibited inflammation (indoniethacin and dexamethasohe), 2a levamisole had no effect in contrast, d-penicillamine potentiated the inflammatory response. Finally the mode of action of the drugs in this method is discussed.
    Authors
    Al-Duaij, Ahmed Yousuf Mohamed
    URI
    http://qmro.qmul.ac.uk/xmlui/handle/123456789/1366
    Collections
    • Theses [3706]
    Copyright statements
    The copyright of this thesis rests with the author and no quotation from it or information derived from it may be published without the prior written consent of the author
    Twitter iconFollow QMUL on Twitter
    Twitter iconFollow QM Research
    Online on twitter
    Facebook iconLike us on Facebook
    • Site Map
    • Privacy and cookies
    • Disclaimer
    • Accessibility
    • Contacts
    • Intranet
    • Current students

    Modern Slavery Statement

    Queen Mary University of London
    Mile End Road
    London E1 4NS
    Tel: +44 (0)20 7882 5555

    © Queen Mary University of London.