Evidence for Dsg3 in regulating Src signaling by competing with it for binding to caveolin-1.
dc.contributor.author | Wan, H | en_US |
dc.contributor.author | Lin, K | en_US |
dc.contributor.author | Tsang, SM | en_US |
dc.contributor.author | Uttagomol, J | en_US |
dc.date.accessioned | 2016-05-16T14:35:44Z | |
dc.date.available | 2015-11-22 | en_US |
dc.date.issued | 2016-03 | en_US |
dc.date.submitted | 2016-03-01T12:24:05.958Z | |
dc.identifier.issn | 2352-3409 | en_US |
dc.identifier.uri | http://qmro.qmul.ac.uk/xmlui/handle/123456789/12355 | |
dc.description.abstract | This data article contains extended, complementary analysis related to the research articles entitled "Desmoglein 3, via an interaction with E-cadherin, is associated with activation of Src" (Tsang et al., 2010) [1] and figures related to the review article entitled "Desmoglein 3: a help or a hindrance in cancer progression?" (Brown et al., 2014) [2]. We show here that both Src and caveolin-1 (Cav-1) associate with Dsg3 in a non-ionic detergent soluble pool and that modulation of Dsg3 levels inversely alters the expression of Src in the Cav-1 complex. Furthermore, immunofluorescence analysis revealed a reduced colocalization of Cav-1/total Src in cells with overexpression of Dsg3 compared to control cells. In support, the sequence analysis has identified a region within the carboxyl-terminus of human Dsg3 for a likelihood of binding to the scaffolding domain of Cav-1, the known Src binding site in Cav-1, and this region is highly conserved across most of 18 species as well as within desmoglein family members. Based on these findings, we propose a working model that Dsg3 activates Src through competing with its inactive form for binding to Cav-1, thus leading to release of Src followed by its auto-activation. | en_US |
dc.format.extent | 124 - 134 | en_US |
dc.language | eng | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Data Brief | en_US |
dc.rights | CC-BY | |
dc.subject | Caveolin | en_US |
dc.subject | Desmoglein | en_US |
dc.subject | Sequence alignment | en_US |
dc.subject | Src signaling | en_US |
dc.title | Evidence for Dsg3 in regulating Src signaling by competing with it for binding to caveolin-1. | en_US |
dc.type | Article | |
dc.rights.holder | © 2016 The Authors | |
dc.identifier.doi | 10.1016/j.dib.2015.11.049 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/26858977 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published online | en_US |
pubs.volume | 6 | en_US |
dcterms.dateAccepted | 2015-11-22 | en_US |
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