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dc.contributor.authorTan, KY
dc.contributor.authorRamstedt, M
dc.contributor.authorColak, B
dc.contributor.authorHuck, WTS
dc.contributor.authorGautrot, JE
dc.date.accessioned2016-05-13T09:57:01Z
dc.date.issued2015-12-16
dc.date.issued2016-01-28
dc.date.submitted2016-05-12T10:00:29.395Z
dc.identifier.issn1759-9954
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/12306
dc.description.abstract© The 2016 Royal Society of Chemistry.Polymer brushes are attractive polymeric coatings for biomedical applications such as tissue engineering, biosensor design and the purification of biological samples. In order to confer bioactivity to these coatings, their functionalisation with biomolecules, proteins and peptides, is required. In this respect, thiol-ene coupling offers interesting features as it is regioselective, efficient and can be controlled by photo-irradiation to allow surface patterning. The efficiency of thiol-ene and the related thiol-yne couplings to poly(glycidyl methacrylate) brushes was quantified. The impact of the structure of thiols to be tethered and reaction conditions on the brush loading and the kinetics of reaction were investigated. Thiol-ene reactions were then used to pattern brushes via direct irradiation through a mask or via reactive micro-contact printing. The resulting patterns were used to control albumin adsorption and the formation of protein patterns.
dc.format.extent979 - 990
dc.language.isoenen_US
dc.titleStudy of thiol-ene chemistry on polymer brushes and application to surface patterning and protein adsorption
dc.typeJournal Article
dc.rights.holder© 2016 The Royal Society of Chemistry
dc.identifier.doi10.1039/c5py01687h
dc.relation.isPartOfPolymer Chemistry
dc.relation.isPartOfPolymer Chemistry
pubs.issue4
pubs.organisational-group/Queen Mary University of London
pubs.organisational-group/Queen Mary University of London/Faculty of Science & Engineering
pubs.organisational-group/Queen Mary University of London/Faculty of Science & Engineering/Engineering and Materials Science - Staff
pubs.publication-statusPublished
pubs.volume7


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