dc.contributor.author | Hamshere, S | |
dc.contributor.author | Jones, DA | |
dc.contributor.author | Pellaton, C | |
dc.contributor.author | Longchamp, D | |
dc.contributor.author | Burchell, T | |
dc.contributor.author | Mohiddin, S | |
dc.contributor.author | Moon, JC | |
dc.contributor.author | Kastrup, J | |
dc.contributor.author | Locca, D | |
dc.contributor.author | Petersen, SE | |
dc.contributor.author | Westwood, M | |
dc.contributor.author | Mathur, A | |
dc.date.accessioned | 2016-03-18T11:59:07Z | |
dc.date.available | 2016-03-18T11:59:07Z | |
dc.date.issued | 2016-01-23 | |
dc.date.submitted | 2016-02-12T07:16:28.903Z | |
dc.identifier.citation | Hamshere, Stephen, Daniel A. Jones, Cyril Pellaton, Danielle Longchamp, Tom Burchell, and Saidi Mohiddin and others, "Cardiovascular Magnetic Resonance Imaging Of Myocardial Oedema Following Acute Myocardial Infarction: Is Whole Heart Coverage Necessary?", Journal of Cardiovascular Magnetic Resonance, 18 (2015) <http://dx.doi.org/10.1186/s12968-016-0226-5> | en_US |
dc.identifier.issn | 1097-6647 | |
dc.identifier.uri | http://qmro.qmul.ac.uk/xmlui/handle/123456789/11510 | |
dc.description.abstract | © 2016 Hamshere et al. Background: AAR measurement is useful when assessing the efficacy of reperfusion therapy and novel cardioprotective agents after myocardial infarction. Multi-slice (Typically 10-12) T2-STIR has been used widely for its measurement, typically with a short axis stack (SAX) covering the entire left ventricle, which can result in long acquisition times and multiple breath holds. This study sought to compare 3-slice T2-short-tau inversion recovery (T2- STIR) technique against conventional multi-slice T2-STIR technique for the assessment of area at risk (AAR). Methods: CMR imaging was performed on 167 patients after successful primary percutaneous coronary intervention. 82 patients underwent a novel 3-slice SAX protocol and 85 patients underwent standard 10-slice SAX protocol. AAR was obtained by manual endocardial and epicardial contour mapping followed by a semi- automated selection of normal myocardium; the volume was expressed as mass (%) by two independent observers. Results: 85 patients underwent both 10-slice and 3-slice imaging assessment showing a significant and strong correlation (intraclass correlation coefficient = 0.92;p < 0.0001) and a low Bland-Altman limit (mean difference -0.03 ± 3.21 %, 95 % limit of agreement,- 6.3 to 6.3) between the 2 analysis techniques. A further 82 patients underwent 3-slice imaging alone, both the 3-slice and the 10-slice techniques showed statistically significant correlations with angiographic risk scores (3-slice to BARI r = 0.36, 3-slice to APPROACH r = 0.42, 10-slice to BARI r = 0.27, 10-slice to APPROACH r = 0.46). There was low inter-observer variability demonstrated in the 3-slice technique, which was comparable to the 10-slice method (z = 1.035, p = 0.15). Acquisition and analysis times were quicker in the 3-slice compared to the 10-slice method (3-slice median time: 100 seconds (IQR: 65-171 s) vs (10-slice time: 355 seconds (IQR: 275-603 s); p < 0.0001. Conclusions: AAR measured using 3-slice T2-STIR technique correlates well with standard 10-slice techniques, with no significant bias demonstrated in assessing the AAR. The 3-slice technique requires less time to perform and analyse and is therefore advantageous for both patients and clinicians. | en_US |
dc.publisher | BioMed Central | en_US |
dc.relation.isreplacedby | 123456789/18023 | |
dc.relation.isreplacedby | http://qmro.qmul.ac.uk/xmlui/handle/123456789/18023 | |
dc.rights | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | |
dc.title | Cardiovascular magnetic resonance imaging of myocardial oedema following acute myocardial infarction: Is whole heart coverage necessary? | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1186/s12968-016-0226-5 | |
dc.relation.isPartOf | Journal of Cardiovascular Magnetic Resonance | |
pubs.issue | 1 | |
pubs.volume | 18 | |