Browsing Library Administration by Subject "Neoplasms"

Now showing items 1-4 of 4

    • Normal Somatic Mutations in Cancer Transformation. 

      Wijewardhane, N; Dressler, L; Ciccarelli, FD (2021-02-08)
      Gene alterations play a prominent role in driving cancer initiation and progression. However, the genetic events that occur in normal cells prior to tumorigenesis are still unknown. Recent studies have started to map somatic ...

    • Oncogenic c-Myc induces replication stress by increasing cohesins chromatin occupancy in a CTCF-dependent manner. 

      Peripolli, S; Meneguello, L; Perrod, C; Singh, T; Patel, H; Rahman, ST; Kiso, K; Thorpe, P; Calvanese, V; Bertoli, C (2024-02-21)
      Oncogene-induced replication stress is a crucial driver of genomic instability and one of the key events contributing to the onset and evolution of cancer. Despite its critical role in cancer, the mechanisms that generate ...

    • Radiation Reveal: Moving from research engagement to involvement. 

      Whittaker, L; Dean, JA; Veiga, C; Langdon, S; Drake, R; Taylor, D; Williams, M-C; Masters, H; Britton, A; Cumbo, M (Springer Nature, 2024-04-13)
      Here, we report on the process of a highly impactful and successful creative, collaborative, and multi-partner public engagement project, Radiation Reveal. It brought together ten young adults aged 17-25-year-olds with ...

    • Somatic variation in normal tissues: friend or foe of cancer early detection? 

      Acha-Sagredo, A; Ganguli, P; Ciccarelli, FD (Elsevier, 2022-09-23)
      BACKGROUND: Seemingly normal tissues progressively become populated by mutant clones over time. Most of these clones bear mutations in well-known cancer genes but only rarely do they transform into cancer. This poses ...