Browsing Library Administration by Subject "LGR5 stem cell"

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    • USP7 inactivation suppresses APC-mutant intestinal hyperproliferation and tumor development 

      Novellasdemunt, L; Kucharska, A; Baulies, A; Hutton, C; Vlachogiannis, G; Repana, D; Rowan, A; Suárez-Bonnet, A; Ciccarelli, F; Valeri, N (Cell Press, 2023-01-19)
      Adenomatous polyposis coli (APC) mutation is the hallmark of colorectal cancer (CRC), resulting in constitutive WNT activation. Despite decades of research, targeting WNT signaling in cancer remains challenging due to its ...