Browsing Library Administration by Subject "Disease Models, Animal"

Now showing items 1-2 of 2

    • Distinct, dosage-sensitive requirements for the autism-associated factor CHD8 during cortical development. 

      Hurley, S; Mohan, C; Suetterlin, P; Ellingford, R; Riegman, KLH; Ellegood, J; Caruso, A; Michetti, C; Brock, O; Evans, R (2021-02-24)
      BACKGROUND: CHD8 haploinsufficiency causes autism and macrocephaly with high penetrance in the human population. Chd8 heterozygous mice exhibit relatively subtle brain overgrowth and little gene expression changes in the ...

    • Skin-resident innate lymphoid cells converge on a pathogenic effector state. 

      Bielecki, P; Riesenfeld, SJ; Hütter, J-C; Torlai Triglia, E; Kowalczyk, MS; Ricardo-Gonzalez, RR; Lian, M; Amezcua Vesely, MC; Kroehling, L; Xu, H (2021-04)
      Tissue-resident innate lymphoid cells (ILCs) help sustain barrier function and respond to local signals. ILCs are traditionally classified as ILC1, ILC2 or ILC3 on the basis of their expression of specific transcription ...