Browsing Library Administration by Author "Megia-Fernandez, A"
Now showing items 1-5 of 5
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A fluorogenic peptide-based smartprobe for the detection of neutrophil extracellular traps and inflammation
Rios, MR; Garoffolo, G; Rinaldi, G; Megia-Fernandez, A; Ferrari, S; Robb, CT; Rossi, AG; Pesce, M; Bradley, M (2021) -
A fluorogenic, peptide-based probe for the detection of Cathepsin D in macrophages.
Rodriguez-Rios, M; McHugh, BJ; Liang, Z; Megia-Fernandez, A; Lilienkampf, A; Dockrell, D; Bradley, M (2023-11-02)Cathepsin D is a protease that is an effector in the immune response of macrophages, yet to date, only a limited number of probes have been developed for its detection. Herein, we report a water soluble, highly sensitive, ... -
Moving into the red - a near infra-red optical probe for analysis of human neutrophil elastase in activated neutrophils and neutrophil extracellular traps.
Rodriguez-Rios, M; Rinaldi, G; Megia-Fernandez, A; Lilienkampf, A; Robb, CT; Rossi, AG; Bradley, M (2023-09-11)Neutrophils are the first immune cells recruited for defence against invading pathogens; however, their dysregulated activation and subsequent release of the enzyme human neutrophil elastase is associated with several, ... -
Optical Detection of Distal Lung Enzyme Activity in Human Inflammatory Lung Disease.
Megia-Fernandez, A; Marshall, A; Akram, AR; Mills, B; Chankeshwara, SV; Scholefield, E; Miele, A; McGorum, BC; Michaels, C; Knighton, N (2021)Objective and Impact Statement. There is a need to develop platforms delineating inflammatory biology of the distal human lung. We describe a platform technology approach to detect in situ enzyme activity and observe drug ... -
Peptide probes for proteases - innovations and applications for monitoring proteolytic activity.
Rodriguez-Rios, M; Megia-Fernandez, A; Norman, DJ; Bradley, M (2022-03-21)Proteases are excellent biomarkers for a variety of diseases, offer multiple opportunities for diagnostic applications and are valuable targets for therapy. From a chemistry-based perspective this review discusses and ...