Browsing Library Administration by Author "Ciccarelli, FD"

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    • Normal Somatic Mutations in Cancer Transformation. 

      Wijewardhane, N; Dressler, L; Ciccarelli, FD (2021-02-08)
      Gene alterations play a prominent role in driving cancer initiation and progression. However, the genetic events that occur in normal cells prior to tumorigenesis are still unknown. Recent studies have started to map somatic ...

    • Somatic variation in normal tissues: friend or foe of cancer early detection? 

      Acha-Sagredo, A; Ganguli, P; Ciccarelli, FD (Elsevier, 2022-09-23)
      BACKGROUND: Seemingly normal tissues progressively become populated by mutant clones over time. Most of these clones bear mutations in well-known cancer genes but only rarely do they transform into cancer. This poses ...