Browsing Library Administration by Author "Ciccarelli, F"
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ImmunoCluster provides a computational framework for the nonspecialist to profile high-dimensional cytometry data.
Opzoomer, JW; Timms, JA; Blighe, K; Mourikis, TP; Chapuis, N; Bekoe, R; Kareemaghay, S; Nocerino, P; Apollonio, B; Ramsay, AG (2021-04-30)High-dimensional cytometry is an innovative tool for immune monitoring in health and disease, and it has provided novel insight into the underlying biology as well as biomarkers for a variety of diseases. However, the ... -
Topoisomerase I poison-triggered immune gene activation is markedly reduced in human small-cell lung cancers by impairment of the cGAS/STING pathway.
Marinello, J; Arleo, A; Russo, M; Delcuratolo, M; Ciccarelli, F; Pommier, Y; Capranico, G (Cell Press, 2022-10-07)BACKGROUND: Current immunotherapy strategies have contrasting clinical results in human lung cancer patients as small-cell lung cancers (SCLC) often show features of immunological cold tumours. Topoisomerase 1 (TOP1) poisons ... -
USP7 inactivation suppresses APC-mutant intestinal hyperproliferation and tumor development
Novellasdemunt, L; Kucharska, A; Baulies, A; Hutton, C; Vlachogiannis, G; Repana, D; Rowan, A; Suárez-Bonnet, A; Ciccarelli, F; Valeri, N (Cell Press, 2023-01-19)Adenomatous polyposis coli (APC) mutation is the hallmark of colorectal cancer (CRC), resulting in constitutive WNT activation. Despite decades of research, targeting WNT signaling in cancer remains challenging due to its ...