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Molecular genetic analysis in the hereditary vitreoretinopathies
(2010)
‘Hereditary vitreoretinopathy’ encompasses a group of inherited disorders characterized by an abnormal appearance to the vitreous gel of the eye. These conditions have a reputation among ophthalmologists for consisting ...
The effects of parenteral or dietary omega-3 polyunsaturated fatty acids in rat models of spinal cord injury
(2010)
There is currently no effective treatment for spinal cord injury (SCI). Long chain omega-3 polyunsaturated fatty acids (PUFA) such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) have beneficial effects in ...
Trafficking and signalling of oncogenic met
(2010)
The Receptor Tyrosine Kinase (RTK) Met influences behaviour of several
cancers by controlling growth, survival and metastasis. Recently,
compartmentalisation of signals generated by RTKs, due to their
endocytosis / ...
Discovery of novel molecular and biochemical predictors of response and outcome in diffuse large B-cell lymphoma
(2009)
Discovery of Novel Molecular and Biochemical Predictors
of Response and Outcome in Diffuse Large B-cell Lymphoma
Diffuse large B-cell lymphoma (DLBCL) is the commonest form of non-Hodgkin
lymphoma and responds to treatment ...
An escherichia coli vaccine co-expressing listeriolysin-O and tumour antigen in cancer immunotherapy and the mechanisms of immune regulation
(2009)
Some recombinant bacterial strains have been shown to be very efficient in
experimental therapies against cancer in rodent models. Amongst them is an E. coli
that expresses the Listeriolysin-O protein (LLO) and a model ...
Studies on the behaviour of human pancreatic carcinoma cell lines, with particular reference to stem cells
(2010)
Stem cell therapy represents a potential -cell replacement strategy in diabetes and a
pancreatic cancer (PC) stem cell is an attractive therapeutic target in this dire disease.
However, a normal stem cell remains ...
Investigating the roles of the alternative Isoforms of the preTCR alpha (pTα) chain in T cell development
(2010)
The pre-T cell receptor (preTCR) is required for αβ T cell development and hence efficient adaptive immunity. Composed of a rearranged TCRβ chain paired with the invariant preTCR α chain (pTα), it drives immature thymocytes ...
Global analysis of SNPs, proteins and protein-protein interactions: approaches for the prioritisation of candidate disease genes.
(2009)
Understanding the etiology of complex disease remains a challenge in biology. In recent
years there has been an explosion in biological data, this study investigates machine
learning and network analysis methods as tools ...
Determining new functions of Adenovirus VA-RNAI and its use in cancer therapy
(2009)
Virus-Associated RNA I (VA-RNAI; VAI) of adenovirus is a nontranslated
RNA molecule known to interact with several dsRNA-binding
molecules in host cells. Adenovirus lacking VA-RNAI shows reduced
replication and toxicity ...
The impact of molecular alterations and the immune microenvironment on the natural history of Follicular Lymphoma including transformation to Diffuse Large B cell Lymphoma
(2009)
The natural history of follicular lymphoma is heterogeneous with numerous relapses
and remissions over many years. A substantial number of patients suffer an
aggressive disease course with death due to disease within 5 ...