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Molecular Characterization of Perineural Invasion in Pancreatic Ductal Adenocarcinoma: Proteomic Analysis and In Vitro Modelling.
(Queen Mary University of London, 2013-09)
Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer, and the 5th most common cause of cancer death in the UK. One of the peculiarities of this malignancy is its ability to invade nerves, a ...
Activity of oncolytic vaccinia virus vectors in ovarian cancer.
(Queen Mary University of London, 2012-03)
Oncolytic vaccinia virus has great potential in the treatment of cancer and two engineered
strains have entered clinical trials. As the advent for oncolytic vaccinia virus as an approved
therapy beckons, it is critical ...
Sensitization of prostate cancer cells to cytotoxic drugs induced by the small adenoviral E1A12S protein through multiple cell death/signalling pathways..
(Queen Mary University of London, 2013-09)
Replication-selective oncolytic adenoviruses represent a promising anticancer approach with proven efficacy in cancer cell lines and tumour xenografts in vivo. Anti-tumour efficacy, both in preclinical studies and clinical ...
Constitutive expression of the AR corepressor, Hey1, from a nonreplicating adenovirus, sensitises prostate cancer cells to chemotherapeutic agents through multiple pathways.
(Queen Mary University of London, 2013-06)
Androgen receptor (AR) cell signalling is active in most castration-resistant
prostate cancer (PCa) tumours and suppression is hypothesized to impede cell
proliferation. Hey1, a corepressor of AR is being investigated ...
Molecular Mechanisms of Lymphatic Invasion in Pancreatic Ductal Adenocarcinoma.
(Queen Mary University of London, 2012-05)
Pancreatic Ductal Adenocarcinoma (PDAC) is one of the five leading causes of cancer-related deaths in the West, and this, largely, is due to metastatic disease. In order to better understand PDAC metastatic spread and ...
Identification of novel therapeutics for the treatment of MMR deficient tumours using high-throughput screens.
(Queen Mary University of London, 2015-05)
The DNA Mismatch repair (MMR) pathway is responsible for the repair of base-base mismatches and insertion/deletion loops, formed during DNA replication. Mutations in MMR genes significantly increase the predisposition to ...
British palaeoclimates and palaeoenvironments during the Hoxnian interglacial (Marine Isotope Stage 11).
(Queen Mary University of London, 13/11/2015)
The Hoxnian interglacial can be correlated with Marine Isotope Stage 11 (MIS 11), which is one of the most significant interglacials in the Pleistocene. MIS 11 is widely believed to be an analogue for the current interglacial, ...
Measurement of the production cross section of a W boson with a single charm quark using the ATLAS detector at the Large Hadron Collider.
(Queen Mary University of London, 2014)
This thesis presents the measurement of the production cross section of a W boson with a single charm quark in 7 TeV proton-proton collisions using the ATLAS
detector at the Large Hadron Collider. The data analysed ...
Control of analgesic and anti-inflammatory pathways by fatty acid amide hydrolase
(Queen Mary University of London, 2012)
The endogenous cannabinoids (endocannabinoids) arachidonoyl ethanolamide (AEA)
and 2-arachidonoyl glycerol (2-AG) regulate neurotransmission and inflammation by
activating the CB1 cannabinoid receptors in the central ...