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The potential therapeutic role of selenium in diffuse large B-cell lymphoma
(2011)
The clinical background to this work confirms the very poor outcome of patients with recurrent diffuse large B-cell lymphoma (DLBCL) and highlights the need for better therapies. One such potential option would be to add ...
Systematic analysis of genomic alterations in prostate cancer
(2011)
Prostate cancer is the most common male cancer in Western countries. The genetic
mechanism underlying its initiation and progression is still unclear. The aim of this
project was to identify novel genomic changes in ...
Apoptosis and mitotic slippage following drug intervention in leukaemia cells
(2011)
The response of leukaemia cells to therapeutic agents includes cell cycle arrest and apoptosis. The former response is useful in retarding disease progression, but induction of the latter is essential for disease eradication. ...
Role of peroxisome proliferator-activated receptor-β/δ in acute myocardial infarction, septic shock and sepsis
(2011)
Peroxisome Proliferator-Activated Receptors (PPARs) are ligand activated transcription factors that belong to the nuclear hormone receptor family. In this thesis, I have investigated the anti-inflammatory role of PPAR-β/δ ...
Human psychophysiological responses to visceral and somatic pain – the development of integrated, reproducible human pain phenotypes
(2011)
Background
Pain is the ubiquitous human experience, yet displays considerable inter- and intraindividual
variability in health and disease. Many factors have been proposed to
account for these differences. Pain ...
Studies of pathophysiology and psychosocial functioning in adolescents with anorectal anomalies
(2011)
Introduction: Anorectal anomalies (ARA) are a range of congenital conditions ranging
from a slight malposition of the anus to complex anomalies of the hindgut and urogenital
organ. Despite advanced surgical and treatment ...
Quality of life in intestinal failure
(2011)
Aims/objectives: The objectives of this research were to investigate and compare aspects
of Quality of Life (QoL) in adult patients who require HPN, in adult patients who have
pseudo-obstruction, and in carers of, and ...
Investigating the role of Bmi-1 in liver growth and function
(2011)
Bmi-1 is a member of the Polycomb group (PcG) family of transcriptional repressors, which are implicated in the maintenance of embryonic and adult stem cells. Previous reports indicate that Bmi-1 plays a key role in ...
Clinical and biological implications of ΔNp63α - an emerging therapeutic oncological target gene
(2011)
The p63 gene encodes multiple protein isoforms that function as sequence specific transcription factors, which can regulate both p53 dependent and independant target genes. Of these, ΔNp63α has been identified as one of ...
Tumour–stroma interactions in an organotypic culture model of pancreatic cancer
(2011)
Pancreatic cancer is characterised by an intense fibrotic, or desmoplastic, stroma,
which contributes to tumour progression. Three-dimensional in vitro culture
models incorporating this non-tumour component may more ...