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The role of airway infection in chronic obstructive pulmonary disease
(2006)
This. thesis examines the role of respiratory bacterial and viral infection in the natural
history of Chronic Obstructive Pulmonary Disease. The rationale for this study is
basedu pon previous data demonstratingt hat ...
Pharmacokinetic studies for the development of transdermal drug delivery systems
(2007)
This thesis mainly describes a series of Phase I pharmacokinetic studies conducted on
the TDS®d elivery systemw hich combinedw ith lidocaine,t estosteronea, nd a new drug,
Melanotan-I for the transdermal drug delivery. ...
Biomechanical effects of patellar taping in subjects with patellofemoral pain syndrome (PFPS).
(2008)
Patellofemoral pain syndrome (PFPS) is one of the most common musculoskeletal
disorders affecting adults. Patellar taping provides an effective treatment in
alleviating the symptoms of a high proportion of subjects who ...
Harlequin ichthyosis and ABCA12
(2012)
Harlequin ichthyosis (HI), a rare severe form of congenital ichthyosis is caused by recessive mutations in the ABCA12 gene. At birth, affected neonates have widespread, grossly thickened skin, separated by deep red fissures, ...
The role of soluble FMS-like tyrosine kinase (sFLT1) and FAS associated proteins in pregnancies complicated by preeclampsia and intrauterine growth restriction (IUGR).
(2005)
Current thinking suggests that preeclampsia is associated with activation of the
maternal vascular endothelium in response to factors released from the placenta due to
placental hypoxia. Failure of physiological modification ...
Protein and gene expression analyses in bone marrow stem cells mediated restoration of myocardium after ischemic insult
(2010)
Myocardial Infarction (MI) is caused by occlusion of the coronary artery following
atheromatous plaque rupture, the subsequent ischemia in the myocardium leads to
myocyte necrosis unless treated quickly. Bone marrow ...
Tumour–stroma interactions in an organotypic culture model of pancreatic cancer
(2011)
Pancreatic cancer is characterised by an intense fibrotic, or desmoplastic, stroma,
which contributes to tumour progression. Three-dimensional in vitro culture
models incorporating this non-tumour component may more ...
The role of humoral autoimmunity in gastrointestinal neuromuscular diseases
(2010)
Dysfunction of the gastrointestinal neuromuscular apparatus (including interstitial cells of Cajal) is presumed to underlie a heterogeneous group of disorders collectively termed gastrointestinal neuromuscular diseases ...
Enteral nutrition feeding strategies and their impact on relapse rate and quality of life in paediatric Crohn’s disease
(2010)
Aims:
To study induction of remission and reduction in relapse rate of
childhood Crohn’s disease with quality of life (QOL) assessment in
subjects on long term continuous oral supplementation with
ACD004.
Methods:
This ...
Microarray analysis of tamoxifen resistance in breast cancer.
(2009)
Tamoxifen remains a widely used hormone therapy for pre and postmenopausal
women with hormone receptor positive breast cancer in both
adjuvant and metastatic disease settings. Resistance to this well tolerated
and ...