dc.contributor.author | D'Onofrio, A | |
dc.contributor.author | Hill, RG | |
dc.contributor.author | Kent, NW | |
dc.contributor.author | Rawlinson, SCF | |
dc.contributor.author | Shahdad, SA | |
dc.date.accessioned | 2024-04-26T11:55:46Z | |
dc.date.available | 2024-04-26T11:55:46Z | |
dc.date.issued | 2024-01-08 | |
dc.identifier.issn | 1616-301X | |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/96473 | |
dc.description.abstract | Particulate bone grafting material can travel from the implantation site and diminish the magnitude of required bone formation response and hence its effectiveness. An easily prepared moldable graft that rapidly sets rigid in situ would alleviate this problem and in this study, such an injectable bone graft material is presented. By combining calcium phosphate (CP) salts with a bioactive glass (BG) mixed with a 2.5% Na2HPO4 solution a novel BG-based calcium phosphate cement (CPC) is produced. Immersion in Tris buffer and simulated body fluid (SBF) solutions result in the rapid generation of octacalcium phosphate (OCP) and hydroxyapatite (HA) phases – a pre-requisite for “bioactivity”. Cement-conditioned media does not result in any cytotoxic potential with respect to MTT activity, DNA content, or alkaline phosphatase activity with an osteoblastic cell line. Application of the cement into standardized surgical defects in the minipig mandible results in short-term, moderate irritation at 3 and 6 weeks and complete replacement of cement with new bone at 12 weeks. | en_US |
dc.language.iso | es | en_US |
dc.publisher | Wiley-VCH GmbH | en_US |
dc.relation.ispartof | Advanced Functional Materials | |
dc.rights | This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | |
dc.title | Development of a Novel Formulation of Bioactive Glass Based Calcium Phosphate Cement for Bone Grafting | en_US |
dc.type | Article | en_US |
dc.rights.holder | © 2024 The Authors. Advanced Functional Materials published by Wiley-VCH GmbH | |
dc.identifier.doi | 10.1002/adfm.202401953 | |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |
qmul.funder | Preclinical Development of a Novel Bioactive Glass Cement for Bone Graft Substitution in Dentistry::Medical Research Council | en_US |