dc.contributor.author | Mathur, MB | |
dc.contributor.author | VanderWeele, TJ | |
dc.date.accessioned | 2024-01-03T10:19:46Z | |
dc.date.available | 2021-12-03 | |
dc.date.available | 2024-01-03T10:19:46Z | |
dc.date.issued | 2022-02 | |
dc.identifier.issn | 0160-4120 | |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/93302 | |
dc.description.abstract | In a recent concept paper (Verbeek et al., 2021), the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) Working Group provides a preliminary proposal to improve its existing guidelines for assessing sensitivity to uncontrolled confounding in meta-analyses of nonrandomized studies. The new proposal centers on reporting the E-value for the meta-analytic mean and on comparing this E-value to a measured "reference confounder" to determine whether residual uncontrolled confounding in the meta-analyzed studies could or could not plausibly explain away the meta-analytic mean. Although we agree that E-value analogs for meta-analyses could be an informative addition to future GRADE guidelines, we suggest improvements to the Verbeek et al. (2021)'s specific proposal regarding: (1) their interpretation of comparisons between the E-value and the strengths of associations of a reference confounder; (2) their characterization of evidence strength in meta-analyses in terms of only the meta-analytic mean; and (3) the possibility of confounding bias that is heterogeneous across studies. | en_US |
dc.format.extent | 107032 | |
dc.language | eng | |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.ispartof | Environment International | |
dc.rights | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | |
dc.subject | Bias | en_US |
dc.subject | Confounding | en_US |
dc.subject | Meta-analysis | en_US |
dc.subject | Observational studies | en_US |
dc.subject | Sensitivity analysis | en_US |
dc.subject | Bias | en_US |
dc.subject | GRADE Approach | en_US |
dc.title | How to report E-values for meta-analyses: Recommended improvements and additions to the new GRADE approach. | en_US |
dc.type | Article | en_US |
dc.rights.holder | © 2022 The Authors. Published by Elsevier Ltd. | |
dc.identifier.doi | 10.1016/j.envint.2021.107032 | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/34954645 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.publisher-url | http://doi.org/10.1016/j.envint.2021.107032 | |
pubs.volume | 160 | en_US |
dcterms.dateAccepted | 2021-12-03 | |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |