Molecular nature of breakdown of the folic acid under hydrothermal treatment: a combined experimental and DFT study
| dc.contributor.author | Abramova, AM | |
| dc.contributor.author | Kokorina, AA | |
| dc.contributor.author | Sindeeva, OA | |
| dc.contributor.author | Jolibois, F | |
| dc.contributor.author | Puech, P | |
| dc.contributor.author | Sukhorukov, GB | |
| dc.contributor.author | Goryacheva, IY | |
| dc.contributor.author | Sapelkin, AV | |
| dc.date.accessioned | 2021-08-05T10:14:46Z | |
| dc.date.available | 2020-10-27 | |
| dc.date.available | 2021-08-05T10:14:46Z | |
| dc.date.issued | 2020-11-12 | |
| dc.identifier.issn | 2045-2322 | |
| dc.identifier.other | ARTN 19668 | |
| dc.identifier.other | ARTN 19668 | |
| dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/73462 | |
| dc.description.abstract | Using a combination of experimental Raman, FTIR, UV–VIS absorption and emission data, together with the corresponding DFT calculations we propose the mechanism of modification of the folic acid specifically under the hydrothermal treatment at 200 °C. We established that folic acid breaks down into fragments while the pteridine moiety remains intact likely evolving into 6-formylpterin with the latter responsible for the increase in fluorescence emission at 450 nm. The results suggest that hydrothermal approach can be used for production of other purpose-engineered fluorophores. | en_US |
| dc.publisher | Nature Publishing Group | en_US |
| dc.relation.ispartof | SCIENTIFIC REPORTS | |
| dc.rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.title | Molecular nature of breakdown of the folic acid under hydrothermal treatment: a combined experimental and DFT study | en_US |
| dc.type | Article | en_US |
| dc.rights.holder | © 2020, The Author(s) | |
| dc.identifier.doi | 10.1038/s41598-020-76311-y | |
| pubs.author-url | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000595255700061&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=612ae0d773dcbdba3046f6df545e9f6a | en_US |
| pubs.issue | 1 | en_US |
| pubs.notes | Not known | en_US |
| pubs.publication-status | Published | en_US |
| pubs.volume | 10 | en_US |
| rioxxterms.funder | Default funder | en_US |
| rioxxterms.identifier.project | Default project | en_US |
| qmul.funder | Targeted drug delivery to neurons and glia using light- and field-sensitive microcapsules::Biotechnology and Biological Sciences Research Council | en_US |
Files in this item
This item appears in the following Collection(s)
-
Physics and Astronomy [1330]
Except where otherwise noted, this item's license is described as This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
