dc.contributor.author | Sleibi, A | en_US |
dc.contributor.author | Tappuni, AR | en_US |
dc.contributor.author | Davis, GR | en_US |
dc.contributor.author | Anderson, P | en_US |
dc.contributor.author | Baysan, A | en_US |
dc.date.accessioned | 2018-06-26T08:01:45Z | |
dc.date.available | 2018-04-13 | en_US |
dc.date.issued | 2018-06 | en_US |
dc.date.submitted | 2018-04-13T15:12:31.916Z | |
dc.identifier.uri | http://qmro.qmul.ac.uk/xmlui/handle/123456789/40343 | |
dc.description.abstract | OBJECTIVES: To compare the efficacy of fluoride varnishes either casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) or bioglass particles on the severity index of root caries. METHODS: Visual-tactile assessments including lesion hardness was carried out to categorise the severity index of 80 extracted teeth with primary root caries. These teeth were randomly divided into four groups; CPP-ACP and fluoride, bioglass and fluoride, fluoride only, and no treatment. Standardised toothbrushing using a dentifrice containing 1450 ppm fluoride was carried out twice a day for all groups. All samples were stored in remineralising solution at 37°C for 45 days. Visual-tactile assessments were carried out at baseline, and after 45 days. Surface roughness measurements (Ra) were performed at baseline and after 7, 14, 30 and 45 days. X-ray Microtomography was performed at the baseline and after 45 days for three samples from each group to quantify the change in mineral contents in the lesion area. RESULTS: The Visual-tactile assessment results showed a reduction in the severity index of root caries, being 20% in CPP-ACP and fluoride, 100% in bioglass and fluoride, 80% in fluoride only, and 60% in non-varnish (toothbrushing only). Non-significant change in surface roughness was observed in all groups. X-ray Microtomography assessment showed a highly significant increase in the mineral deposition in all cases (p > .001). CONCLUSION: The combination of bioglass with fluoride has a potentially superior effect than either CPP-ACP with fluoride or fluoride only to reverse and arrest the root caries in a laboratory setting. CLINICAL SIGNIFICANCE: The combination of bioglass particles and fluoride formulation is likely to have a significant impact in reversing and arresting root caries in a minimally invasive approach. However, randomised controlled double-blinded clinical trials are required to translate these results into clinical practice. | en_US |
dc.description.sponsorship | This work was financially supported by the Ministry of Higher Education in Iraqi as a part of a PhD project. The authors declare no potential conflicts of interest with respect to publication of this article. | en_US |
dc.format.extent | 91 - 96 | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | J Dent | en_US |
dc.rights | © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject | Bioglass | en_US |
dc.subject | CPP-ACP | en_US |
dc.subject | Dental varnish | en_US |
dc.subject | Root caries | en_US |
dc.subject | Surface roughness | en_US |
dc.subject | XMT | en_US |
dc.title | Comparison of efficacy of dental varnish containing fluoride either with CPP-ACP or bioglass on root caries: Ex vivo study. | en_US |
dc.type | Article | |
dc.rights.holder | Crown Copyright © 2018 Published by Elsevier Ltd. All rights reserved. | |
dc.identifier.doi | 10.1016/j.jdent.2018.04.009 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/29673685 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 73 | en_US |
dcterms.dateAccepted | 2018-04-12 | en_US |