dc.contributor.author | JOHAL, A | en_US |
dc.contributor.author | Jahaur, P | en_US |
dc.contributor.author | Al-quattan, F | en_US |
dc.contributor.author | Kassim, S | en_US |
dc.contributor.author | Mc Cloughlin, K | en_US |
dc.date.accessioned | 2016-11-25T11:45:51Z | |
dc.date.available | 2016-11-02 | en_US |
dc.date.issued | 2016-11-05 | en_US |
dc.date.submitted | 2016-11-16T15:28:16.762Z | |
dc.identifier.uri | http://qmro.qmul.ac.uk/xmlui/handle/123456789/17884 | |
dc.description.abstract | Study objectives: Could a clinically safe and reliable compliance measure of mandibular advancement appliance (MAA) therapy demonstrate a high level of therapeutic efficacy, in patients diagnosed with moderate OSAHS. Study design and participants: A long-term prospective observational study was undertaken in which patients with moderate OSAHS and in whom CPAP use had failed, to determine treatment compliance with MAA therapy, after a minimum period of 18 months, using an objective monitor. Treatment outcomes included both objective sleep monitoring and a determination of the therapeutic efficacy based on the calculation of the mean disease alleviation (MDA). Results: Forty-two patients, with moderate OSAHS (mean AHI of 21.0 [+/- 10.3] events/hour) completed the study, at 18–month follow-up. A statistically significant difference (p<0.001; 95%CI 2.76, 3.50) was observed between the objectively recorded use of the MAA appliance (7.13 hours) and the predetermined gold standard level of 4 hours. A highly statistically significant reduction (p<0.001) was observed in follow-up ESS (7.2 +/- 3.3) and AHI (4.7 +/- 3.0) scores, which in turn was evidenced by the calculated therapeutic efficacy of 75.1% (95CI 70.9, 79.2) and a MDA of 70% (95CI 63.7, 76.3). Conclusion: The study demonstrates the safe long-term objective measurement of compliance and comparable levels of therapeutic efficacy for MAA therapy in patients with moderate OSAHS, providing new evidence of the role of MAA therapy as a viable alternative in patients unable to tolerate CPAP. | en_US |
dc.description.sponsorship | A small charities grant was awarded to help purchase the objective monitoring sensors | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Journal of Sleep Disorders and Management | en_US |
dc.rights | Open Access by ClinMed International Library is licensed under a Creative Commons Attribution 4.0 International License based on a work at http://clinmedjournals.org/. | |
dc.subject | Observational study | en_US |
dc.subject | mandibular appliances | en_US |
dc.subject | sleep apnoea | en_US |
dc.subject | compliance | en_US |
dc.title | The efficacy of mandibular advancement appliances as a treatment alternative to continuous positive airway pressure in moderate OSAHS | en_US |
dc.type | Article | |
dc.rights.holder | (c) The Author(s) 2016. | |
dc.identifier.doi | 10.23937/2572-4053.1510013 | en_US |
pubs.notes | Not known | en_US |
pubs.notes | Open access Journal | en_US |
pubs.publication-status | Published | en_US |
dcterms.dateAccepted | 2016-11-02 | en_US |