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The global clonal complexity of the murine blood system declines throughout life and after serial transplantation.
(2019-05-02)
Although many recent studies describe the emergence and prevalence of "clonal hematopoiesis of indeterminate potential" in aged human populations, a systematic analysis of the numbers of clones supporting steady-state ...
Nfix Promotes Survival of Immature Hematopoietic Cells via Regulation of c-Mpl.
(2018-02-12)
Hematopoietic stem and progenitor cells (HSPCs) are necessary for life-long blood production and replenishment of the hematopoietic system during stress. We recently reported that nuclear factor I/X (Nfix) promotes HSPC ...
Murine hematopoietic stem cell activity is derived from pre-circulation embryos but not yolk sacs.
(2018-12-20)
The embryonic site of definitive hematopoietic stem cell (dHSC) origination has been debated for decades. Although an intra-embryonic origin is well supported, the yolk sac (YS) contribution to adult hematopoiesis remains ...
Cdk7: open questions beyond the prevailing model.
(2012-10-01)
Murine hemogenic endothelial precursors display heterogeneous hematopoietic potential ex vivo.
(2017-07)
Hematopoietic stem and progenitor cells (HSPCs) sustain life-long hematopoiesis and are first detected in the embryo by transplantation at embryonic day 10.5 (E10.5). HSPCs are mesodermal in origin and ultimately emerge ...