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Functional screen identifies regulators of murine hematopoietic stem cell repopulation.
(2016-03-07)
Understanding the molecular regulation of hematopoietic stem and progenitor cell (HSPC) engraftment is paramount to improving transplant outcomes. To discover novel regulators of HSPC repopulation, we transplanted >1,300 ...
Lifelong haematopoiesis is established by hundreds of precursors throughout mammalian ontogeny.
(2017-10)
Current dogma asserts that mammalian lifelong blood production is established by a small number of blood progenitors. However, this model is based on assays that require the disruption, transplantation and/or culture of ...
Nfix Promotes Survival of Immature Hematopoietic Cells via Regulation of c-Mpl.
(2018-02-12)
Hematopoietic stem and progenitor cells (HSPCs) are necessary for life-long blood production and replenishment of the hematopoietic system during stress. We recently reported that nuclear factor I/X (Nfix) promotes HSPC ...