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Estimating the distribution of selection coefficients from phylogenetic data using sitewise mutation-selection models.
(2012-03)
Estimation of the distribution of selection coefficients of mutations is a long-standing issue in molecular evolution. In addition to population-based methods, the distribution can be estimated from DNA sequence data by ...
The culture of care within psychiatric services: tackling inequalities and improving clinical and organisational capabilities.
(2012-09-28)
INTRODUCTION: Cultural Consultation is a clinical process that emerged from anthropological critiques of mental healthcare. It includes attention to therapeutic communication, research observations and research methods ...
A synthesis of the evidence for managing stress at work: a review of the reviews reporting on anxiety, depression, and absenteeism.
(2012)
BACKGROUND: Psychosocial stressors in the workplace are a cause of anxiety and depressive illnesses, suicide and family disruption. METHODS: The present review synthesizes the evidence from existing systematic reviews ...
Downregulation of the serum response factor/miR-1 axis in the quadriceps of patients with COPD.
(2012-01)
RATIONALE: Muscle atrophy confers a poor prognosis in patients with chronic obstructive pulmonary disease (COPD), yet the molecular pathways responsible are poorly characterised. Muscle-specific microRNAs and serum response ...
Pre-cooling for endurance exercise performance in the heat: a systematic review.
(2012)
Endurance exercise capacity diminishes under hot environmental conditions. Time to exhaustion can be increased by lowering body temperature prior to exercise (pre-cooling). This systematic literature review synthesizes the ...
Perceptions of changes in practice following peer review in the National Chronic Obstructive Pulmonary Disease Resources and Outcomes Project.
(2012)
PURPOSE: The purpose of this paper is to examine perceptions of local service change and concepts of change amongst participants in a UK nationwide randomised controlled trial of informal, structured, reciprocated, ...
Optic disc assessment in the emergency department: a comparative study between the PanOptic and direct ophthalmoscopes.
(2012-12)
Optic disc assessment is an essential part of the neurological examination of acutely unwell patients. This study compares the PanOptic ophthalmoscope with the direct ophthalmoscope for accuracy of diagnosis and ease of ...
Reporting participation rates in studies of non-pharmacological interventions for patients with chronic obstructive pulmonary disease: a systematic review.
(2012-12-29)
UNLABELLED: BACKGROUND: Pulmonary rehabilitation (PR) and self-management (SM) support programmes are effective in the management of patients with chronic obstructive pulmonary disease (COPD), but these interventions are ...