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Characterization and Differentiation of Three British Population Groups
(Queen Mary University of London, 2013-05)
The British population is made up of three main ethnic groups: Caucasian, Afro-
Caribbean and South Asian. The history of Britain is littered with a series of invasion
and colonisation events, potentially resulting in a ...
The role of voltage-gated sodium channel 1.9 (Nav1.9) in visceral afferent signalling.
(Queen Mary University of London, 2013-06)
Abdominal pain places a large burden on society and its current management is sub-optimal due to the lack of visceral-specific analgesics. Voltage-gated sodium channels (Nav) are crucial for action potential generation and ...
Molecular Characterization of Perineural Invasion in Pancreatic Ductal Adenocarcinoma: Proteomic Analysis and In Vitro Modelling.
(Queen Mary University of London, 2013-09)
Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer, and the 5th most common cause of cancer death in the UK. One of the peculiarities of this malignancy is its ability to invade nerves, a ...
Functional Characterisation of the Genes Mutated in Dyskeratosis Congenita.
(Queen Mary University of London, 2013-02)
Dyskeratosis congenita (DC) is a multi system disorder that exhibits considerable clinical and genetic heterogeneity. It is characterised by mucocutaneous features, bone marrow failure and a predisposition to cancer. ...
Investigating the functional significance of an FGFR2 intronic SNP in Breast Cancer
(Queen Mary University of London, 2013-05)
Single nucleotide polymorphisms present in the second intron of the fibroblast growth factor receptor 2 (FGFR2) gene have been linked with increased risk of breast cancer in several genome wide association studies. The ...
Interactions between primary cilia length and hedgehog signalling in response to mechanical and thermal stress.
(Queen Mary University of London, 2013-06)
The primary cilium is a microtubule-based organelle present on the majority of interphase
cells where it functions as a hub for numerous signalling pathways including hedgehog
signalling. Chondrocytes, the unique cellular ...
Novel roles of human desmoglein 3 in the regulation of E-cadherin-mediated adherens junctions and the reorganisation of actin cytoskeleton.
(Queen Mary University of London, 2013-04)
Desmosomes and adherens junctions are intercellular junctions crucial for epithelial cell-cell adhesion and maintenance of normal tissue architecture. Desmoglein 3 (Dsg3), a member of the desmoglein sub-family, serves as ...
Epigenetic variation associated with genetic and environmental factors in the aetiology of Type 2 diabetes.
(Queen Mary University of London, 2013-02)
Type 2 diabetes, as a complex disease, has a range of genetic and environmental factors that underpin its aetiology. It is hoped that the emerging study of epigenetic processes will provide the necessary mechanistic insight ...
Clinical evaluation of a new optical fibre method of measuring oxygen saturation using photoplethysmograph signals reflected from internal tissues
(Queen Mary University of London, 2013-06)
Traditional methods of measuring oxygen saturation, e.g. pulse oximetry, depend on
an adequate peripheral circulation and have a 20–30 second lag time before readings
are obtained. This was a series of evaluations of ...
The expression of Suppressor of Cytokine Signalling (SOCS), JAK-STAT signalling pathway and cytokine profile in Behçet’s Disease
(Queen Mary University of London, 2013-08)
Behçet’s disease (BD) is a chronic, multi systemic, recurrent vasculitis disease of unknown aetiology. The clinical manifestations are composed of relapsing episodes of recurrent oral ulcers, uveitis, skin lesions and ...