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European Society of Biomechanics S.M. Perren Award 2012: the external mechanical environment can override the influence of local substrate in determining stem cell fate.

Thorpe, SD; Buckley, CT; Steward, AJ; Kelly, DJ (2012-10-11)

The aim of this study was to explore how cell-matrix interactions and extrinsic mechanical signals interact to determine stem cell fate in response to transforming growth factor-β3 (TGF-β3). Bone marrow derived mesenchymal ...

Cell-matrix interactions regulate mesenchymal stem cell response to hydrostatic pressure.

Steward, AJ; Thorpe, SD; Vinardell, T; Buckley, CT; Wagner, DR; Kelly, DJ (2012-07)

Both hydrostatic pressure (HP) and cell-matrix interactions have independently been shown to regulate the chondrogenic differentiation of mesenchymal stem cells (MSCs). The objective of this study was to test the hypothesis ...