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Transcription factors early growth response gene (Egr) 2 and 3 control inflammatory responses of tolerant T cells.
INTRODUCTION: Impaired proliferation and production of IL2 are the hallmarks of experimental T cell tolerance. However, in most autoimmune diseases, auto-reactive T cells do not display hyper proliferation, but inflammatory ...
T-cell reconstitution after thymus xenotransplantation induces hair depigmentation and loss.
Here we present a mouse model for T-cell targeting of hair follicles, linking the pathogenesis of alopecia to that of depigmentation disorders. Clinically, thymus transplantation has been successfully used to treat T-cell ...