Now showing items 1-4 of 4
The Significance of C-Met in Different Molecular Sub-Types of Invasive Breast Cancer.
(Queen Mary University of London, 2014-05)
Introduction: Basal-like (BL) breast cancer is an aggressive sub-type of breast cancer for which there is no targeted systemic therapy. C-Met is a receptor tyrosine kinase implicated in breast cancer. Clinical trials ...
Investigating the functional significance of an FGFR2 intronic SNP in Breast Cancer
(Queen Mary University of London, 2013-05)
Single nucleotide polymorphisms present in the second intron of the fibroblast growth factor receptor 2 (FGFR2) gene have been linked with increased risk of breast cancer in several genome wide association studies. The ...
Investigation of the Functional Significance of MMP-8 in Breast Myoepithelial Cells.
(Queen Mary University of London, 2013)
The Matrix Metalloproteinase (MMP) family are conventionally considered as key enzymes contributing to cancer-cell invasion through remodelling of the extracellular matrix (ECM). In contrast, MMP-8 has been shown to exert ...
Activating senescence in p16-positive Basal-like breast cancer.
(Activating senescence in p16-positive Basal-like breast cancer., 2016-01-05)
Breast cancer is the most common cancer in the UK and Basal-like breast cancer (a highly aggressive subtype) accounts for approximately 8-22% of all cases depending on ethnicity. Unlike most human malignancies and indeed ...