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Characterisation of Proendothelin-1 Derived Peptides and Evaluation of Their Utility as Biomarkers of Vascular and Renal Pathologies
(Queen Mary University of London, 02/06/2014)
Endothelin-1 (ET-1), the potent vasoconstrictor peptide, is synthesised from the 212 amino acid precursor preproendothelin-1 (ppET-1). ET-1 is strongly implicated in cardiac and renal pathologies. However, ET receptor ...
Optimal Relaxed Designs of Experiments, with Pharmaceutical Applications
(Queen Mary University of London, 2014-06)
This thesis was motivated by the collaborative research undertaken by QMUL and Pfizer UK
into improving experiments at pre-clinical drug development. In theory, the most efficient
designs for these particular experiments, ...