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Mechanism of Ciclosporin-induced gingival hyperplasia An in vitro study of the effect of ciclosporin on human gingival fibroblasts and oral keratinocytes
(2011)
Objectives:
Ciclosporin (CsA) is a potent and effective immuno-suppressive drug, but its use is associated with the development of gingival hyperplasia in up to 70% of patients.
The mechanism underlying this side effect ...
Clinical & experimental characterisation of acute traumatic coagulopathy
(2011)
Acute traumatic coagulopathy (ATC) is a recently identified entity describing an early impairment of haemostasis after injury. Retrospective observational studies have associated it with a significant increase in patient ...
The effect of oligomeric procyanidins on endothelial function and cholesterol homeostasis
(2012)
Oligomeric procyanidins (OPC) are naturally occurring dietary substances, which studies
suggest can protect against cardiovascular disease. To explore this further a double-blind
randomised controlled crossover trial, ...
Arming vaccinia virus for pancreatic cancer oncolytic virotherapy
(2011)
Vaccinia virus is a 250-300nm enveloped DNA virus from the poxvirus family and is used as a vector for oncolytic viral gene therapy. No unique cell surface receptor has been identified for Vaccinia virus and the reasons ...
Investigation of the role of the p110β isoform of PI 3-kinase in cell signalling and proliferation
(2011)
Phosphoinositide 3-kinases (PI3Ks) are signalling enzymes that play important roles in various cellular processes and in disease, such as cancer and auto-immunity. There are several isoforms of PI3K whose individual roles ...
TP63 is implicated in apoptotic dysregulation in melanoma
(2010)
Cutaneous melanoma is an aggressive malignancy accounting for 4% of skin cancers but 80% of all skin-cancer related deaths. Its incidence is rapidly rising and advanced disease is notoriously treatment-resistant. The role ...
Self-harm in East London adolescents
(2010)
The prevalence of adolescent self-harm is higher in the community compared with self-harm monitored through service use, as only a minority of young people seek help. There has been limited longitudinal community-based ...
An exploration of the association between khat chewing and health outcomes in UK-resident male Yemeni khat chewers
(2010)
Aims: 1) To identify the characteristics of a sample of Yemeni Khat chewers in Sheffield. 2) To investigate how these characteristics are associated with: a) Self-rated "compromised‟ health. b) Self-reported oral health ...
The roles of Fibroblast Growth Factor 22 in development, tissue repair and homeostasis, and the associated role of FGF signalling in skin cancer.
(2010)
Fibroblast Growth Factors (FGFs) play critical roles during development,
tissue homeostasis and repair and in controlling cell proliferation, survival,
migration and differentiation. Of the 22 mammalian FGFs, FGF22, a ...
A novel method of thrombelastograph analysis aids assessment of antiplatelet therapy in percutaneous coronary intervention.
(2010)
Background
A near-patient test of responses to antiplatelet therapy would be of great value in percutaneous coronary intervention (PCI). However, at present, there are no widely accepted tests and varied definitions of ...