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Synthesis and characterization of novel low band gap semiconducting polymers for organic photovoltaic and organic field effect transistor applications
(Queen Mary University of London, 2012)
This thesis describes the synthesis, characterization and device properties of a range of conjugated polymers incorporating 3,6-dilakylthieno[3,2-b]thiophene. We report a new and facile synthesis for the preparation of ...
Next-Generation Sequencing Analysis of DNA Methylation in Acute Myeloid Leukaemia
(2012)
DNA methylation has an emerging role in pathogenesis and diagnosis of acute myeloid leukaemia (AML). In order to obtain a global view of the DNA methylation changes in AML genome, we applied methylated DNA immunoprecipitation ...
Inhibition of Mammalian Target of Rapamycin (mTOR) in Epidermis
(Queen Mary University of London, 2012)
Cutaneous squamous cell carcinoma (cSCC) is one of the most common Caucasian skin cancers and is particularly prevalent following chronic ultraviolet (UV) radiation exposure and in immunosuppressed patients. Recent use of ...
Investigating the effects of Chromosome 21 genes on pathological angiogenesis
(Queen Mary University of London, 2012)
Patients with trisomy of chromosome 21, known as Down’s syndrome (DS), have a
lower incidence of solid tumours than unaffected age-matched individuals. However,
the cellular and molecular basis for this observation is ...
Mechanisms of evolution in antibiotic resistant clones of Streptococcus pneumoniae
(Queen Mary University of London, 2012-12)
Streptococcus pneumoniae has a highly adaptable genome due at least in part to its
natural transformability and its ability to recombine with other pneumococci and
related species. The emergence of antibiotic resistant ...
Ischaemic and Pharmacological Preconditioning of the Uraemic Heart.
(Queen Mary University of London, 2011)
The incidence and mortality from cardiovascular disease (CVD) in patients with
chronic kidney disease (CKD) far exceeds that seen in the general population.
Whilst a number of risk factors and associations have been ...
Promoting the survival, migration and integration of Schwann cells by over-expression of polysialic acid
(2011)
The poor survival and migration of transplanted Schwann cells (SCs) are major drawbacks for their clinical application in cell therapy for neurotrauma. To overcome such drawbacks we genetically modified SCs to over-express ...
Prenatal identification of trisomy 18 (Edwards syndrome)
(2011)
This thesis provides a literature review of trisomy 18 (Edwards syndrome) with a focus
on the use of maternal serum and ultrasound markers in the late first and early second
trimester of pregnancy to aid in identifying ...
Primary tissue-based proteomic analysis of apoptosis-regulating pathways in malignant pleural mesothelioma (MPM)
(2011)
Malignant pleural mesothelioma (MPM) is an aggressive and fatal malignancy associated with resistance to chemotherapy and radiotherapy. Programmed cell death or apoptosis underlies the efficacy of cytotoxic anti-cancer ...
Optimal Relaxed Designs of Experiments, with Pharmaceutical Applications
(Queen Mary University of London, 2014-06)
This thesis was motivated by the collaborative research undertaken by QMUL and Pfizer UK
into improving experiments at pre-clinical drug development. In theory, the most efficient
designs for these particular experiments, ...