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Cdk7: open questions beyond the prevailing model.
(2012-10-01)
Small molecule chemokine mimetics suggest a molecular basis for the observation that CXCL10 and CXCL11 are allosteric ligands of CXCR3.
(2012-06)
BACKGROUND AND PURPOSE: The chemokine receptor CXCR3 directs migration of T-cells in response to the ligands CXCL9/Mig, CXCL10/IP-10 and CXCL11/I-TAC. Both ligands and receptors are implicated in the pathogenesis of ...
Endogenous endophthalmitis and liver abscesses.
(2012)
We present a case of endogenous endophthalmitis secondary to liver abscesses, in a patient with no previous medical comorbidities or risk factors for immunosuppression. The patient presented with acute painless loss of ...
FUS-SMN protein interactions link the motor neuron diseases ALS and SMA
(Cell Press, 2012-09-27)
Mutations in the RNA binding protein FUS cause amyotrophic lateral sclerosis (ALS), a fatal adult motor neuron disease. Decreased expression of SMN causes the fatal childhood motor neuron disorder spinal muscular atrophy ...
Extending application of the 'hardcore' definition to smokeless tobacco use: estimates from a nationally representative population in India and its implications.
(2012)
BACKGROUND: The term 'hardcore' has been applied to use of smoking tobacco and generally referred to as the inability or unwillingness of regular smokers to quit. The component constructs of hardcore except nicotine ...
Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability
(National Academy of Sciences, 2012-03-26)
Transactive response DNA-binding (TDP-43) protein is the dominant disease protein in amyotrophic lateral sclerosis (ALS) and a subgroup of frontotemporal lobar degeneration (FTLD-TDP). Identification of mutations in the ...
Health system preparedness for tobacco control: situational analysis of existing health programs in andhra pradesh, India.
(2012)
INTRODUCTION: Andhra Pradesh (AP) is one of the largest tobacco producing states in India. About 29% of adults in AP currently use tobacco in some form. Almost 24% of males and 4% of females are smokers. The prevalence of ...
Trends in missed presentations and late HIV diagnosis in a UK teaching hospital: a retrospective comparative cohort study.
(2012-03-28)
BACKGROUND: Late diagnosis is an important cause of HIV-related morbidity, mortality and healthcare costs in the UK and undiagnosed infection limits efforts to reduce transmission. National guidelines provide recommendations ...
Attenuated, oncolytic, but not wild-type measles virus infection has pleiotropic effects on human neutrophil function.
(2012-02-01)
We previously showed that neutrophils play a role in regression of human tumor xenografts in immunodeficient mice following oncolytic vaccine measles virus (MV-Vac) treatment. In this study, we sought, using normal human ...