Browsing by Subject "Centrioles"
Now showing items 1-4 of 4
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Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly.
(2013-09-17)Centrioles organise centrosomes and template cilia and flagella. Several centriole and centrosome proteins have been linked to microcephaly (MCPH), a neuro-developmental disease associated with small brain size. CPAP (MCPH6) ... -
Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly.
(2018-04-30)Centrosomes are required for faithful chromosome segregation during mitosis. They are composed of a centriole pair that recruits and organizes the microtubule-nucleating pericentriolar material. Centriole duplication is ... -
Disease-Associated Mutations in CEP120 Destabilize the Protein and Impair Ciliogenesis.
(2018-05-29)Ciliopathies are a group of genetic disorders caused by a failure to form functional cilia. Due to a lack of structural information, it is currently poorly understood how ciliopathic mutations affect protein functionality ... -
Structural validation and assessment of AlphaFold2 predictions for centrosomal and centriolar proteins and their complexes.
(2022-04-05)Obtaining the high-resolution structures of proteins and their complexes is a crucial aspect of understanding the mechanisms of life. Experimental structure determination methods are time-consuming, expensive and cannot ...