Browsing by Author "Willems, SM"
Now showing items 1-20 of 24
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Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
Surendran, P; Feofanova, EV; Lahrouchi, N; Ntalla, I; Karthikeyan, S; Cook, J; Chen, L; Mifsud, B; Yao, C; Kraja, AT (2020) -
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals (vol 52, pg 1314, 2020)
Surendran, P; Feofanova, EV; Lahrouchi, N; Ntalla, I; Karthikeyan, S; Cook, J; Chen, L; Mifsud, B; Yao, C; Kraja, AT (2021) -
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
Evangelou, E; Warren, HR; Mosen-Ansorena, D; Mifsu, B; Pazoki, R; Gao, H; Ntritsos, G; Dimou, N; Cabrer, CP; Karaman, I (2018-10) -
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci
Gaulton, KJ; Ferreira, T; Lee, Y; Raimondo, A; Maegi, R; Reschen, ME; Mahajan, A; Locke, A; Rayner, NW; Robertson, N (2015-12) -
Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus
van Zuydam, NR; Ladenvall, C; Voight, BF; Strawbridge, RJ; Fernandez-Tajes, J; Rayner, NW; Robertson, NR; Mahajan, A; Vlachopoulou, E; Goel, A (Wolters Kluwer Health, Inc. on behalf of the American Heart Association,, 2020-08-13) -
A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease
Scott, RA; Freitag, DF; Li, L; Chu, AY; Surendran, P; Young, R; Grarup, N; Stancakova, A; Chen, Y; Varga, TV (2016-06-01) -
GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification.
Lagou, V; Jiang, L; Ulrich, A; Zudina, L; González, KSG; Balkhiyarova, Z; Faggian, A; Maina, JG; Chen, S; Todorov, PV (2023-09)Conventional measurements of fasting and postprandial blood glucose levels investigated in genome-wide association studies (GWAS) cannot capture the effects of DNA variability on 'around the clock' glucoregulatory processes. ... -
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility
Wessel, J; Chu, AY; Willems, SM; Wang, S; Yaghootkar, H; Brody, JA; Dauriz, M; Hivert, M-F; Raghavan, S; Lipovich, L (2015-01) -
A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
Ried, JS; Jeff, JM; Chu, AY; Bragg-Gresham, JL; van Dongen, J; Huffman, JE; Ahluwalia, TS; Cadby, G; Eklund, N; Eriksson, J (2016-11-23) -
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
Turcot, V; Lu, Y; Highland, HM; Schurmann, C; Justice, AE; Fine, RS; Bradfield, JP; Esko, T; Giri, A; Graff, M (2018-01) -
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (vol 50, pg 26, 2017)
Turcot, V; Lu, Y; Highland, HM; Schurmann, C; Justice, AE; Fine, RS; Bradfield, JP; Esko, T; Giri, A; Graff, M (2019-07) -
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (vol 50, pg 26, 2018)
Turcot, V; Lu, Y; Highland, HM; Schurmann, C; Justice, AE; Fine, RS; Bradfield, JP; Esko, T; Giri, A; Graff, M (2018-05) -
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (vol 50, pg 765, 2017)
Turcot, V; Lu, Y; Highland, HM; Schurmann, C; Justice, AE; Fine, RS; Bradfield, JP; Esko, T; Giri, A; Graff, M (2018-05) -
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution.
Justice, AE; Karaderi, T; Highland, HM; Young, KL; Graff, M; Lu, Y; Turcot, V; Auer, PL; Fine, RS; Guo, X (Nature Research (part of Springer Nature), 2019-02-18)Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted ... -
Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
Evangelou, E; Warren, HR; Mosen-Ansorena, D; Mifsud, B; Pazoki, R; Gao, H; Ntritsos, G; Dimou, N; Cabrera, CP; Karaman, I (Nature Research (part of Springer Nature), 2018-11-14)Correction to: Nature Genetics https://doi.org/10.1038/s41588-018-0205-x, published online 17 September 2018. In the version of this article originally published, the name of author Martin H. de Borst was coded incorrectly ... -
Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.
Lagou, V; Mägi, R; Hottenga, J-J; Grallert, H; Perry, JRB; Bouatia-Naji, N; Marullo, L; Rybin, D; Jansen, R; Min, JL (2021-02-08)Correction to: Nature Communications https://doi.org/10.1038/s41467-020-19366-9, published online 5 January 2021. The original version of this Article contained an error in Fig. 2, in which panels a and b were inadvertently ... -
Rare and low-frequency coding variants alter human adult height
Marouli, E; Graff, M; Medina-Gomez, C; Lo, KS; Wood, AR; Kjaer, TR; Fine, RS; Lu, Y; Schurmann, C; Highland, HM (2017-02-09) -
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes
Mahajan, A; Wessel, J; Willems, SM; Zhao, W; Robertson, NR; Chu, AY; Gan, W; Kitajima, H; Taliun, D; Rayner, NW (Nature Research (part of Springer Nature), 2018-04-09)We aggregated coding variant data for 81,412 type 2 diabetes cases and 370,832 controls of diverse ancestry, identifying 40 coding variant association signals (P < 2.2 × 10−7); of these, 16 map outside known risk-associated ... -
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.
Lagou, V; Mägi, R; Hottenga, J-J; Grallert, H; Perry, JRB; Bouatia-Naji, N; Marullo, L; Rybin, D; Jansen, R; Min, JL (Nature Research, 2021-01-05)Differences between sexes contribute to variation in the levels of fasting glucose and insulin. Epidemiological studies established a higher prevalence of impaired fasting glucose in men and impaired glucose tolerance in ... -
Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy.
Lechner, M; Schartinger, VH; Steele, CD; Nei, WL; Ooft, ML; Schreiber, L-M; Pipinikas, CP; Chung, GT-Y; Chan, YY; Wu, F (2021-01-05)Nasopharyngeal cancer (NPC), endemic in Southeast Asia, lacks effective diagnostic and therapeutic strategies. Even in high-income countries the 5-year survival rate for stage IV NPC is less than 40%. Here we report high ...