Now showing items 1-4 of 4

    • Investigation of Autosomal Genetic Sex Differences in Parkinson's disease. 

      Blauwendraat, C; Iwaki, H; Makarious, MB; Bandres-Ciga, S; Leonard, H; Grenn, FP; Lake, J; Krohn, L; Tan, M; Kim, JJ (2021-04-26)
      OBJECTIVE: Parkinson's disease (PD) is a complex neurodegenerative disorder. Males are on average ~ 1.5 times more likely to develop PD compared to females with European ancestry. Over the years genome-wide association ...
    • Mitochondria function associated genes contribute to Parkinson's Disease risk and later age at onset 

      Billingsley, KJ; Barbosa, IA; Bandres-Ciga, S; Quinn, JP; Bubb, VJ; Deshpande, C; Botia, JA; Reynolds, RH; Zhang, D; Simpson, MA (Springer Nature, 2019-05-22)
      Mitochondrial dysfunction has been implicated in the etiology of monogenic Parkinson’s disease (PD). Yet the role that mitochondrial processes play in the most common form of the disease; sporadic PD, is yet to be fully ...
    • Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson's disease heritability 

      Reynolds, RH; Botia, J; Nalls, MA; Hardy, J; Taliun, SAG; Ryten, M; Noyce, AJ; Nicolas, A; Cookson, MR; Bandres-Ciga, S (Springer Nature, 2019-04-17)
      Parkinson’s disease (PD), with its characteristic loss of nigrostriatal dopaminergic neurons and deposition of α-synuclein in neurons, is often considered a neuronal disorder. However, in recent years substantial evidence ...
    • Parkinson's disease in GTP cyclohydrolase 1 mutation carriers. 

      Mencacci, NE; Isaias, IU; Reich, MM; Ganos, C; Plagnol, V; Polke, JM; Bras, J; Hersheson, J; Stamelou, M; Pittman, AM (2014-09)
      GTP cyclohydrolase 1, encoded by the GCH1 gene, is an essential enzyme for dopamine production in nigrostriatal cells. Loss-of-function mutations in GCH1 result in severe reduction of dopamine synthesis in nigrostriatal ...