Browsing by Author "O'Brien, A"
Now showing items 1-7 of 7
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Albumin Counteracts Immune-Suppressive Effects of Lipid Mediators in Patients With Advanced Liver Disease.
China, L; Maini, A; Skene, SS; Shabir, Z; Sylvestre, Y; Colas, RA; Ly, L; Becares Salles, N; Belloti, V; Dalli, J (2018-05)BACKGROUND & AIMS: Patients with acute decompensation and acute-on-chronic liver failure (AD/ACLF) have immune dysfunction, which increases their risk for infections; however, there are no effective treatments to restore ... -
Bile duct-ligated mice exhibit multiple phenotypic similarities to acute decompensation patients despite histological differences
O'Brien, A; China, L; Massey, KA; Nicolaou, A; Winstanley, A; Newson, J; Hobbs, A; Audzevich, T; Gilroy, DW (2016-06) -
Follow the money: how is medical school teaching funded?
O'Brien, A; Korszun, A (Cambridge University Press, 2020-07-13)Growing student numbers are producing greater demand for teaching, and resources allocated for education are being placed under increasing strain. The need for more student clinical placements and more clinician teaching ... -
Immune Regulatory Mediators in Plasma from Patients with Acute Decompensation are Associated With 3-month Mortality.
Becares, N; Härmälä, S; China, L; Colas, RA; Maini, AA; Bennet, K; Skene, SS; Shabir, Z; Dalli, J; O'Brien, A (2019-08-22)BACKGROUND & AIMS: Infection is a common cause of death in patients with cirrhosis. We investigated the association between the innate immune response and death within 3 months of hospitalization. METHODS: Plasma samples ... -
Plasma lipid mediator (LM) profiling identifies hyper- and hypo-activated groups of patients with ACLF and targeted 20% human albumin solution infusion recalibrates abnormalities
China, L; Maini, A; Colas, R; Ly, L; Dalli, J; Gilroy, D; O'Brien, A; Infection, ATTIREAP (2017) -
Systemic Inflammatory Response Syndrome After Major Abdominal Surgery Predicted by Early Upregulation of TLR4 and TLR5
Lahiri, R; Derwa, Y; Bashir, Z; Giles, E; Torrance, HDT; Owen, HC; O'Dwyer, MJ; O'Brien, A; Stagg, AJ; Bhattacharya, S (2016-05) -
Using healthcare systems data for outcomes in clinical trials: issues to consider at the design stage.
Toader, A-M; Campbell, MK; Quint, JK; Robling, M; Sydes, MR; Thorn, J; Wright-Hughes, A; Yu, L-M; Abbott, TEF; Bond, S (2024-01-29)BACKGROUND: Healthcare system data (HSD) are increasingly used in clinical trials, augmenting or replacing traditional methods of collecting outcome data. This study, PRIMORANT, set out to identify, in the UK context, ...