Browsing by Author "Noursadeghi, M"
Now showing items 1-20 of 32
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Antibody response to first BNT162b2 dose in previously SARS-CoV-2-infected individuals
Manisty, C; Otter, AD; Treibel, TA; McKnight, A; Altmann, DM; Brooks, T; Noursadeghi, M; Boyton, RJ; Semper, A; Moon, JC (2021) -
Blood transcriptional biomarkers of acute viral infection for detection of pre-symptomatic SARS-CoV-2 infection: a nested, case-control diagnostic accuracy study.
Gupta, RK; Rosenheim, J; Bell, LC; Chandran, A; Guerra-Assuncao, JA; Pollara, G; Whelan, M; Artico, J; Joy, G; Kurdi, H (Elsevier, 2021-07-06)Background: We hypothesised that host-response biomarkers of viral infections might contribute to early identification of individuals infected with SARS-CoV-2, which is critical to breaking the chains of transmission. We ... -
Blood transcriptomic diagnosis of pulmonary and extrapulmonary tuberculosis.
Roe, JK; Thomas, N; Gil, E; Best, K; Tsaliki, E; Morris-Jones, S; Stafford, S; Simpson, N; Witt, KD; Chain, B (2016-10-06)BACKGROUND. Novel rapid diagnostics for active tuberculosis (TB) are required to overcome the time delays and inadequate sensitivity of current microbiological tests that are critically dependent on sampling the site of ... -
Blood Transcriptomic Stratification of Short-term Risk in Contacts of Tuberculosis.
Roe, J; Venturini, C; Gupta, RK; Gurry, C; Chain, BM; Sun, Y; Southern, J; Jackson, C; Lipman, MC; Miller, RF (2020-02-14)BACKGROUND: The highest risk of tuberculosis arises in the first few months after exposure. We reasoned that this risk reflects incipient disease among tuberculosis contacts. Blood transcriptional biomarkers of tuberculosis ... -
COVID-19: PCR screening of asymptomatic healthcare workers at London hospital
Treibel, TA; Manisty, C; Burton, M; McKnight, A; Lambourne, J; Augusto, JB; Couto-Parada, X; Cutino-Moguel, T; Noursadeghi, M; Moon, JC (2020-05-23) -
Detection of <i>M. tuberculosis</i> DNA in CD34-Positive Peripheral Blood Mononuclear Cells of Asymptomatic TB Contacts
Belay, M; Tulu, B; Younis, S; Jolliffe, DA; Tayachew, D; Manwandu, H; Abozen, T; Tirfie, EA; Tegegn, M; Zewude, AHaematopoietic stem cells expressing the CD34 surface marker have been posited as a niche for Mycobacterium tuberculosis complex bacilli during latent tuberculosis infection. Our aim was to determine whether M tuberculosis ... -
Detection of Mycobacterium tuberculosis complex DNA in CD34-positive peripheral blood mononuclear cells of asymptomatic tuberculosis contacts: an observational study
Belay, M; Tulu, B; Younis, S; Jolliffe, DA; Tayachew, D; Manwandu, H; Abozen, T; Tirfie, EA; Tegegn, M; Zewude, A (Elsevier, 2021-03-31) -
Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection.
Reynolds, CJ; Swadling, L; Gibbons, JM; Pade, C; Jensen, MP; Diniz, MO; Schmidt, NM; Butler, DK; Amin, OE; Bailey, SNL (2020-12-23)Understanding the nature of immunity following mild/asymptomatic infection with SARS-CoV-2 is crucial to controlling the pandemic. We analyzed T cell and neutralizing antibody responses in 136 healthcare workers (HCW) 16-18 ... -
Discovery and validation of a personalized risk predictor for incident tuberculosis in low transmission settings.
Gupta, RK; Calderwood, CJ; Yavlinsky, A; Krutikov, M; Quartagno, M; Aichelburg, MC; Altet, N; Diel, R; Dobler, CC; Dominguez, J (2020-10-19)The risk of tuberculosis (TB) is variable among individuals with latent Mycobacterium tuberculosis infection (LTBI), but validated estimates of personalized risk are lacking. In pooled data from 18 systematically identified ... -
Do higher quantitative interferon gamma release assay or tuberculin skin test results help to predict incident tuberculosis? Data from the UK PREDICT study
Gupta, R; Lipman, M; Jackson, C; Sitch, A; Southern, J; Drobniewski, F; Deeks, J; Tsou, C-Y; Griffiths, C; Davidson, J (2019-09-28) -
Enhancement of cutaneous immunity during aging by blocking p38 mitogen-activated protein (MAP) kinase-induced inflammation
Vukmanovic-Stejic, M; Chambers, ES; Suarez-Farinas, M; Sandhu, D; Fuentes-Duculan, J; Patel, N; Agius, E; Lacy, KE; Turner, CT; Larbi, A (Elsevier, 2017-11-16)Background Immunity decreases with age, which leads to reactivation of varicella zoster virus (VZV). In human subjects age-associated immune changes are usually measured in blood leukocytes; however, this might not reflect ... -
ESICM LIVES 2016: part three : Milan, Italy. 1-5 October 2016.
Velasquez, T; Mackey, G; Lusk, J; Kyle, UG; Fontenot, T; Marshall, P; Shekerdemian, LS; Coss-Bu, JA; Nishigaki, A; Yatabe, T (2016-09) -
Evaluation of QuantiFERON-TB Gold Plus for Predicting Incident Tuberculosis among Recent Contacts: A Prospective Cohort Study.
Gupta, RK; Kunst, H; Lipman, M; Noursadeghi, M; Jackson, C; Southern, J; Imran, A; Lozewicz, S; Abubakar, I (American Thoracic Society, 2020-02-21) -
Exaggerated IL-17A activity in human in vivo recall responses discriminates active tuberculosis from latent infection and cured disease.
Pollara, G; Turner, CT; Rosenheim, J; Chandran, A; Bell, LCK; Khan, A; Patel, A; Peralta, LF; Folino, A; Akarca, A (Science Translational Medicine, 2021-05-05)Host immune responses at the site of Mycobacterium tuberculosis infection can mediate pathogenesis of tuberculosis (TB) and onward transmission of infection. We hypothesized that pathological immune responses would be ... -
Exploring a combined biomarker for tuberculosis treatment response: protocol for a prospective observational cohort study.
Kloprogge, F; Abubakar, I; Esmail, H; Hack, V; Kunst, H; McHugh, TD; Noursadeghi, M; Surey, J; Tiberi, S; Lipman, M (BMJ, 2021-07-08)INTRODUCTION: An improved understanding of factors explaining tuberculosis (TB) treatment response is urgently needed to help clinicians optimise and personalise treatment and assist scientists undertaking novel treatment ... -
Healthcare Workers Bioresource: Study outline and baseline characteristics of a prospective healthcare worker cohort to study immune protection and pathogenesis in COVID-19
Augusto, JB; Menacho, K; Andiapen, M; Bowles, R; Burton, M; Welch, S; Bhuva, AN; Seraphim, A; Pade, C; Joy, G (2020-10-12) -
Healthcare Workers Bioresource: Study outline and baseline characteristics of a prospective healthcare worker cohort to study immune protection and pathogenesis in COVID-19
Augusto, JB; Menacho, K; Andiapen, M; Bowles, R; Burton, M; Welch, S; Bhuva, AN; Seraphim, A; Pade, C; Joy, G (2020-10-12) -
Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants
Reynolds, CJ; Gibbons, JM; Pade, C; Lin, K-M; Sandoval, DM; Pieper, F; Butler, DK; Liu, S; Otter, AD; Joy, G (2022) -
HLA-DR polymorphism in SARS-CoV-2 infection and susceptibility to symptomatic COVID-19
Astbury, S; Reynolds, CJ; Butler, DK; Munoz-Sandoval, DC; Lin, K-M; Pieper, FP; Otter, A; Kouraki, A; Cusin, L; Nightingale, J (2022) -
Large clones of pre-existing T cells drive early immunity against SARS-COV-2 and LCMV infection
Milighetti, M; Peng, Y; Tan, C; Mark, M; Nageswaran, G; Byrne, S; Ronel, T; Peacock, T; Mayer, A; Chandran, A (2023)